Association between obesity and Barrett’s esophagus in a Japanese population: a hospital-based, cross-sectional study

BMC Gastroenterology

Research Article

Haruki Asano¹  Jiro Watari¹  Hisatomo Ikehara¹  Hirokazu Fukui¹  Fumihiko Toyoshima¹  Jun Sakurai¹  Tadayuki Oshima¹  Kazutoshi Hori¹  Toshihiko Tomita¹  Zhao Liang Li¹  Hiroto Miwa¹  Noriko Kamiya¹  Takahisa Yamasaki¹  Takashi Kondo¹  Takuya Okugawa¹ 

[1] Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, 1-1, Mukogawa-cho, 663-8501, Nishinomiya, Japan;

关键词: Barrett’s esophagus;    Body mass index;    Waist circumference;    Visceral obesity;    Reflux esophagitis;   

DOI  :  10.1186/1471-230X-13-143

 received in 2013-03-17, accepted in 2013-09-20,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundThe association between obesity and Barrett’s esophagus (BE) in the Japanese population remains unclear. The prevalence of BE and its associated risk factors was examined.MethodsA cross-sectional study of 1581 consecutive individuals who underwent upper gastrointestinal endoscopy was conducted. The prevalence of endoscopically suspected BE (ESBE) was evaluated. Obesity was evaluated by body mass index (BMI, ≥ 25 kg/m2) and waist circumference (WC) (males, ≥ 85 cm; females, ≥ 90 cm). Because endoscopic diagnosis of ultra-short ESBE (<1 cm in extent) is difficult and highly unreliable, this type of ESBE was excluded from the study.ResultsIn proton pump inhibitor (PPI) non-users, the prevalence of ESBE ≥ 1 cm was 5.6%. In univariate analysis, male sex and reflux esophagitis (RE) were significantly associated with BE, but BMI, WC, and reflux symptoms were not. In multivariate logistic regression analysis, only RE (odds ratio [OR] = 3.48, 95% confidence interval [CI] 1.89-6.41, p < 0.0001) was an independent risk factor for BE; obesity and the other factors were not. In contrast, RE (OR 5.67, p = 0.0004) and large WC (OR 5.09, p = 0.0005) were significant risk factors for ESBE ≥ 1 cm in PPI users. Only male sex, but not obesity or the other risk factors, was associated with an increased risk of RE in patients not taking PPIs.ConclusionsRE, but not obesity, may have an independent association with the risk of ESBE in the Japanese population. Furthermore, obesity measures were not independent risks for RE. Interestingly, PPI-refractory RE and large WC were risk factors for ESBE ≥1 cm in patients taking PPIs.

【 授权许可】

CC BY   
© Watari et al.; licensee BioMed Central Ltd. 2013