A case report of primary neuroendocrine carcinoma of the perihilar bile duct

BMC Surgery

Case Report

Michiko Nagamine¹  Takahiro Urata²  Toshihiko Hirata³  Hiroshi Yokomizo³  Yasuhiro Kihara³ 

[1] Division of Diagnostic Pathology, Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan;Division of Gastroenterology, Japanese Red Cross Kumamoto Hospital, Kumamoto, Japan;Division of General Surgery, Japanese Red Cross Kumamoto Hospital, Nagamineminami 2-1-1, Higashiku, 861-8520, Kumamoto city, Kumamoto, Japan;

关键词: Neuroendocrine carcinoma;    Bile duct;    Small cell carcinoma;   

DOI  :  10.1186/s12893-015-0116-z

 received in 2015-09-18, accepted in 2015-12-07,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundAlthough neuroendocrine tumors are most commonly found in the digestive system, neuroendocrine tumors originating from the bile duct are rare, and neuroendocrine carcinomas derived from the perihilar bile duct are extremely rare. This report presents the clinical course and clinicopathological features of neuroendocrine carcinomas arising from the extrahepatic bile duct.Case presentationA 70-year-old Japanese woman was preoperatively diagnosed with perihilar cholangiocarcinoma, and a radical resection with an extended left hepatic lobectomy and a choledochojejunostomy was performed. From the histopathological findings, we diagnosed the tumor as a neuroendocrine carcinoma of the bile duct (small cell type) with lymph node metastasis. The patient was treated with the same adjuvant chemotherapy as that used for small cell carcinoma of the lung. At 10 months after surgery, there was no recurrence of the disease.ConclusionNeuroendocrine carcinoma of the extrahepatic biliary tracts is a very rare and highly malignant disease with a poor prognosis. A multidisciplinary approach could improve the prognosis for this neoplasm.

【 授权许可】

CC BY   
© Kihara et al. 2015