Two additional cases of parotid neuroendocrine carcinoma: Is there a wall that cannot be overcome in the cellular morphology?

Human Pathology Reports

Akihiko Kawahara¹  Hiroshi Harada²  Takeharu Ono³  Hideyuki Abe³  Akira Kurose³  Jun Akiba⁴  Hirohito Umeno⁴ 

[1] Corresponding author at: Department of Anatomic Pathology, Hirosaki University Graduate School of Medicine, 5 Zaifu, Hirosaki 036-8562, Japan.;Department of Anatomic Pathology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan;Department of Diagnostic Pathology, Kurume University Hospital, Kurume, Japan;Department of Otorhinolaryngology and Head and Neck Surgery, Kurume University School of Medicine, Kurume, Japan;

关键词: Small cell carcinoma;    Large cell carcinoma;    Neuroendocrine carcinoma;    Metastasis;    Parotid gland;    Salivary gland;   

DOI  :  

来源: DOAJ

【 摘 要 】

Herein, we summarize two rare cases of salivary neuroendocrine carcinoma arising in the parotid gland. The patients were a 54-year-old Japanese female and a 74-year-old Japanese male. In the first case, the tumor presented as a typical small cell carcinoma with extensive crush artifacts and nuclear molding, but metastatic foci of the lymph node revealed characteristic ribbon-like trabecular arrangements or sheet-like solid growths of tumor cells with moderate amounts of pale eosinophilic cytoplasm intermingled with bizarre giant or multinucleated cells. In the second case, the tumor was initially diagnosed as a small cell neuroendocrine carcinoma, but a retrospective review revealed that the large cell component was dominant and that it should be strictly considered a mixed large and small cell neuroendocrine carcinoma. The difference in prognoses between these two salivary subtypes remains unknown, and distinction between the small and large cell subtypes of neuroendocrine carcinomas seems merely simple and convenient in the salivary glands.

【 授权许可】

Unknown