The association of gout with sleep disorders: a cross-sectional study in primary care

BMC Musculoskeletal Disorders

Research Article

Christian D Mallen¹  Sara Muller¹  Richard Hayward¹  Edward Roddy¹ 

[1] Arthritis Research UK Primary Care Centre, Keele University, Keele, UK;

关键词: Gout;    Sleep;    Apnea;    General practice;    Metabolic syndrome X;   

DOI  :  10.1186/1471-2474-14-119

 received in 2012-05-22, accepted in 2013-04-01,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundBoth gout and sleep apnoea are associated with the metabolic syndrome. Hyperuricaemia is also prevalent in sleep apnoea syndrome. The objective of this study was to examine the association between gout and sleep apnoea and other sleep disorders.MethodsData were taken from a validated database of general practice records from nine practices in the UK between 2001 and 2008. People consulting for gout were identified via Read codes and each matched with four controls for age, gender, practice and year of gout consultation. Sleep problems and confounding comorbidities were also identified via Read codes. Medications were identified through a linked database of prescription records. The association between gout and sleep disorders was assessed using a logistic regression model, adjusting for ischaemic heart disease, hypertension, diabetes mellitus and diuretic use.Results1689 individuals with gout were identified and each successfully matched to four controls. Amongst those with gout, the prevalence of any sleep problem was 4.9%, sleep problems other than sleep apnoea 4.2%, and sleep apnoea 0.7%, compared to 3.5%, 3.2% and 0.3% respectively in controls. Gout was associated with any sleep problem (odds ratio (OR) 1.44; 95% confidence interval (CI) 1.11, 1.87), sleep problems other than sleep apnoea (OR 1.36; 95% CI 1.03, 1.80), and sleep apnoea (OR 2.10; 95% CI 1.01, 4.39). On multivariable analysis, gout remained significantly associated with any sleep problem (OR 1.39; 95% CI 1.06, 1.81) and sleep problems other than sleep apnoea (OR 1.37; 95% CI 1.03, 1.82), however the association with sleep apnoea was attenuated (OR 1.48, 95% CI 0.70, 3.14).ConclusionsGout and sleep problems appear to be associated and clinicians should be aware of the co-existence of these two conditions. Larger prospective epidemiological studies are required to explore causality.

【 授权许可】

CC BY   
© Roddy et al.; licensee BioMed Central Ltd. 2013