Colour Doppler analysis of ophthalmic vessels in the diagnosis of carotic artery and retinal vein occlusion, diabetic retinopathy and glaucoma: systematic review of test accuracy studies

BMC Ophthalmology

Research Article

Reinier O. Schlingemann¹  Sophie C. Boehni²  Mario Bittner²  Martin K. Schmid²  Livia Faes³  Lucas M. Bachmann³ 

[1] Department of Ophthalmology, Academic Medical Center, PO Box 22660, 1100 DD, Amsterdam, The Netherlands;Eye Clinic, Cantonal Hospital of Lucerne, Spitalstrasse, CH-6001, Lucerne, Switzerland;medignition Inc, Verena Conzett-Strasse 9, CH-8004, Zurich, Switzerland;

关键词: Glaucoma;    Diabetic Retinopathy;    Retinal Nerve Fibre Layer;    Retinal Vein Occlusion;    Ophthalmic Artery;   

DOI  :  10.1186/s12886-016-0384-0

 received in 2016-05-06, accepted in 2016-11-10,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundColour Doppler analysis of ophthalmic vessels has been proposed as a promising tool in the diagnosis of various eye diseases, but the available diagnostic evidence has not yet been assessed systematically. We performed a comprehensive systematic review of the literature on the diagnostic properties of Colour Doppler imaging (CDI) assessing ophthalmic vessels and provide an inventory of the available evidence.MethodsEligible papers were searched electronically in (Pre) Medline, Embase and Scopus, and via cross-checking of reference lists. The minimum requirement to be included was the availability of original data and the possibility to construct a two-by-two table. Study selection, critical appraisal using the QUADAS II instrument and extraction of salient study characteristics was made in duplicate. Sensitivity and specificity was computed for each study.ResultsWe included 11 studies (15 two-by-two tables) of moderate methodological quality enrolling 820 participants (range 30 to 118). In 44.4% participants were female (range 37–59% in specific subgroups). CDI was assessed for internal carotid stenosis, diabetic retinopathy, glaucoma, and branch or central retinal vein occlusion diagnosis. There was insufficient data to pool the results for specific illnesses. For the assessments of ophthalmic arteries, mean sensitivity was 0.69 (range 0.27–0.96) with a corresponding mean specificity of 0.83 (range 0.70–0.96). Mean sensitivity of the central retinal artery assessments was 0.58 (range 0.31–0.84) and the corresponding mean specificity was 0.82 (range 0.63–0.94).ConclusionsRobust assessments of the diagnostic value of colour Doppler analysis remain uncommon, limiting the possibilities to extrapolate its true potential for clinical practice.PROSPERO 2014:CRD42014014027.

【 授权许可】

CC BY   
© The Author(s). 2016