Population-based study of ovarian cancer in Côte d'Or: prognostic factors and trends in relative survival rates over the last 20 years

BMC Cancer

Research Article

Patrick Roignot¹  Thierry Altwegg²  Franck Bonnetain³  Marie-Laure Poillot⁴  Sylvain Causeret⁴  Laurent Arnould⁴  Julie Gentil⁵  Tienhan S Dabakuyo⁵  Zeinab Hamidou⁵  Patrick Arveux⁵ 

[1] Centre de Pathologie, 33 rue Nicolas Bornier, 21000, Dijon, France;Centre de Radiothérapie Du Parc, 18 cours du général de Gaulle, 21000, Dijon, France;EA 4184, Université de Bourgogne, 21000, Dijon, France;Unité de Biostatistiques et d'épidémiologie, Centre Georges François Leclerc, 21079, Dijon Cedex, France;Registre des Cancers du Sein et autres Cancers Gynécologiques de Côte d'Or, Centre Georges François Leclerc, Dijon, France;Registre des Cancers du Sein et autres Cancers Gynécologiques de Côte d'Or, Centre Georges François Leclerc, Dijon, France;EA 4184, Université de Bourgogne, 21000, Dijon, France;

关键词: Ovarian Cancer;    Independent Prognostic Factor;    Relative Survival;    Figo Stage;    Relative Survival Rate;   

DOI  :  10.1186/1471-2407-10-622

 received in 2010-06-14, accepted in 2010-11-10,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundThe aim of this population-based study was to assess independent prognostic factors in ovarian cancer using relative survival (RS) and to investigate changes in RS rates from 1982 to 2005.MethodsData on 748 patients with ovarian cancer were provided by the Côte d'Or gynaecologic cancer registry. The RS was estimated using a generalized linear model with a Poisson error structure. Relative survival and its 95% confidence interval (CI) were described at the following specific time points 1, 3 and 5 years. The effect of prognostic factors on survival was assessed with multivariate analyses of RS.ResultsThe median follow-up was 12 years. The RS rates at 1, 3 and 5 years were 81%, 55% and 44%, respectively. As compared with the period 1982-1989, an improvement in survival was found for the period 1998-2005: HR = 0.52[0.40-0.67]. Women who lived in urban areas had better RS: HR = 0.82[0.67-0.99]. Patients with epithelial types of ovarian cancer other than mucinous or endometrioid cancer had worse RS than those with serous histology. Age ≥ 70 years was associated with lower survival.ConclusionsPeriod of diagnosis, stage at diagnosis, histology, place of residence and age were independent prognostic factors for survival in ovarian cancer. An improvement in the survival rate was observed after 1998 but a significant improvement was limited to advanced stage cancers.

【 授权许可】

Unknown   
© Hamidou et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.