The effectiveness of individual interpersonal psychotherapy as a treatment for major depressive disorder in adult outpatients: a systematic review

BMC Psychiatry

Research Article

Madelon L J M van Hees¹  Silvia M A A Evers²  Thomas Rotter³  Tim Ellermann⁴ 

[1] Caphri, School of Public Health and Primary Care; Faculty of Health, Medicine, and Life Sciences, Maastricht University, Maastricht, The Netherlands;Caphri, School of Public Health and Primary Care; Faculty of Health, Medicine, and Life Sciences, Maastricht University, Maastricht, The Netherlands;Caphri, School of Public Health and Primary Care; Department of Health Services Research, Maastricht University, Maastricht, The Netherlands;Caphri, School of Public Health and Primary Care; Faculty of Health, Medicine, and Life Sciences, Maastricht University, Maastricht, The Netherlands;College of Pharmacy and Nutrition, University of Saskatchewan, Saskoon, Canada;Institute for Public Health and Nursing Research (IPP), University of Bremen, Bremen, Germany;

关键词: Interpersonal psychotherapy;    Major depressive disorder;    Systematic review;   

DOI  :  10.1186/1471-244X-13-22

 received in 2011-12-09, accepted in 2013-01-07,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundThis systematic review describes a comparison between several standard treatments for major depressive disorder (MDD) in adult outpatients, with a focus on interpersonal psychotherapy (IPT).MethodsSystematic searches of PubMed and PsycINFO studies between January 1970 and August 2012 were performed to identify (C-)RCTs, in which MDD was a primary diagnosis in adult outpatients receiving individual IPT as a monotherapy compared to other forms of psychotherapy and/or pharmacotherapy.Results1233 patients were included in eight eligible studies, out of which 854 completed treatment in outpatient facilities. IPT combined with nefazodone improved depressive symptoms significantly better than sole nefazodone, while undefined pharmacotherapy combined with clinical management improved symptoms better than sole IPT. IPT or imipramine hydrochloride with clinical management showed a better outcome than placebo with clinical management. Depressive symptoms were reduced more in CBASP (cognitive behavioral analysis system of psychotherapy) patients in comparison with IPT patients, while IPT reduced symptoms better than usual care and wait list condition.ConclusionsThe differences between treatment effects are very small and often they are not significant. Psychotherapeutic treatments such as IPT and CBT, and/or pharmacotherapy are recommended as first-line treatments for depressed adult outpatients, without favoring one of them, although the individual preferences of patients should be taken into consideration in choosing a treatment.

【 授权许可】

CC BY   
© van Hees et al.; licensee BioMed Central Ltd. 2013