The impact of physical activity on fatigue and quality of life in lung cancer patients: a randomised controlled trial protocol

BMC Cancer

Study Protocol

Haryana M Dhillon¹  Janette Vardy²  Melanie L Bell³  Michael Boyer⁴  Stephen Clarke⁵  Hidde P van der Ploeg⁶ 

[1] Centre for Medical Psychology and Evidence-based Decision-making, University of Sydney, Sydney, Australia;Psycho-Oncology Co-Operative Research Group (PoCoG), School of Psychology, Faculty of Science, University of Sydney, Sydney, Australia;Centre for Medical Psychology and Evidence-based Decision-making, University of Sydney, Sydney, Australia;Psycho-Oncology Co-Operative Research Group (PoCoG), School of Psychology, Faculty of Science, University of Sydney, Sydney, Australia;Sydney Cancer Centre, Sydney, Australia;Sydney Medical School, University of Sydney, Sydney, Australia;Sydney Cancer Centre, Concord Repatriation General Hospital, Hospital Rd, 2137, Concord, NSW, Australia;Psycho-Oncology Co-Operative Research Group (PoCoG), School of Psychology, Faculty of Science, University of Sydney, Sydney, Australia;Sydney Cancer Centre, Sydney, Australia;Sydney Medical School, University of Sydney, Sydney, Australia;Royal North Shore Hospital, St Leonards, Australia;Sydney School of Public Health, University of Sydney, Sydney, Australia;Department of Public and Occupational Health, VU University Medical Center Amsterdam, Amsterdam, The Netherlands;

关键词: Physical activity;    Exercise;    Fatigue;    Quality of life;    Lung cancer;   

DOI  :  10.1186/1471-2407-12-572

 received in 2012-07-04, accepted in 2012-11-26,  发布年份 2012

来源: Springer

【 摘 要 】

BackgroundPeople with lung cancer have substantial symptom burden and more unmet needs than the general cancer population. Physical activity (PA) has been shown to positively influence quality of life (QOL), fatigue and daily functioning in the curative treatment of people with breast and colorectal cancers and lung diseases, as well as in palliative settings. A randomised controlled trial (RCT) is needed to determine if lung cancer patients benefit from structured PA intervention. The Physical Activity in Lung Cancer (PAL) trial is designed to evaluate the impact of a 2-month PA intervention on fatigue and QOL in patients with non-resectable lung cancer. Biological mechanisms will also be studied.Methods/designA multi-centre RCT with patients randomised to usual care or a 2-month PA programme, involving supervised PA sessions including a behavioural change component and home-based PA. QOL questionnaires, disease and functional status and body composition will be assessed at baseline, 2, 4 and 6 months follow-up. The primary endpoint is comparative levels of fatigue between the 2 arms. Secondary endpoints include: QOL, functional abilities and physical function. Exploratory endpoints include: anxiety, depression, distress, dyspnoea, PA behaviour, fitness, hospitalisations, survival, cytokines and insulin-like growth factor levels.DiscussionThis study will provide high-level evidence of the effect of PA programmes on cancer-related fatigue and QOL in patients with advanced lung cancer. If positive, the study has the potential to change care for people with cancer using a simple, inexpensive intervention to improve their QOL and help them maintain independent function for as long as possible.Trial registrationAustralian New Zealand Clinical Trials Registry No. ACTRN12609000971235

【 授权许可】

Unknown   
© Dhillon et al.; licensee BioMed Central Ltd. 2012. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.