The effects of Alkanna tinctoria Tausch on split-thickness skin graft donor site management: a randomized, blinded placebo-controlled trial

BMC Complementary and Alternative Medicine

Research Article

Abbas Norouzi Javidan¹  Shahideh Amini²  Mohammad Mehdi Saghafi³  Ghasemali Khorasani⁴  Aliasghar Kheiri⁴ 

[1] Brain and Spinal Injury Research Center, Institute of Neuroscience, Tehran University of Medical Sciences, Tehran, Iran;Clinical Pharmacy Department, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran;Pharmacology Department, Faculty of Pharmacy, Iran University of Medical Sciences, Tehran, Iran;Plastic and Reconstructive Surgery Division, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran;

关键词: Alkanna;    Skin graft;    Wound;    Healing;   

DOI  :  10.1186/s12906-017-1741-0

 received in 2016-04-11, accepted in 2017-04-13,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundA prospective, randomized, placebo-controlled clinical trial was conducted to compare the healing effectiveness of Alkanna tinctoria (L.) Tausch (Boraginaceae) with standard dressing on wound healing at the donor site after removal of the skin graft.MethodsEnrolled patients were randomly allocated to receive topicalA. tinctoria extract ointment (20%) or standard dressing (dressing with base ointment) daily. Wound healing was assessed using the Bates-Jenson assessment tool at the 2nd and 4th weeks after intervention.ResultsDecreases in wound score were significantly greater in the A. tinctoria group compared with the placebo group (P <0.05). The surface areas of graft donor sites in the A. tinctoria group were significantly reduced as compared with the control group at day 28 of the intervention (P < 0.05). The proportion of patients in the A. tinctoria group achieving complete wound healing within 2 to 4 weeks was 50% and 96.66%, respectively, significantly higher than in patients receiving standard care: 0% and 23.3%, respectively.ConclusionsThis clinical study showed that A. tinctoria dressing accelerates wound healing after graft harvesting.Trial registrationIRCT ID: IRCT201511165781N2.

【 授权许可】

CC BY   
© The Author(s). 2017