Curcumin reduces α-synuclein induced cytotoxicity in Parkinson's disease cell model

BMC Neuroscience

Research Article

Michael R Sierks¹  Shanta Boddapati¹  Sharareh Emadi¹  Min S Wang² 

[1] Department of Chemical Engineering, Arizona State University, 85287-6006, Tempe, AZ, USA;Department of Chemical Engineering, Arizona State University, 85287-6006, Tempe, AZ, USA;Department of Chemistry, University of Colorado Denver, 80217-3364, Denver, CO, USA;

关键词: Curcumin;    Reactive Oxygen Species Level;    Intracellular Reactive Oxygen Species Level;    Tris Buffer;    Increase Reactive Oxygen Species Level;   

DOI  :  10.1186/1471-2202-11-57

 received in 2009-07-28, accepted in 2010-04-30,  发布年份 2010

来源: Springer

【 摘 要 】

BackgroundOverexpression and abnormal accumulation of aggregated α-synuclein (αS) have been linked to Parkinson's disease (PD) and other synucleinopathies. αS can misfold and adopt a variety of morphologies but recent studies implicate oligomeric forms as the most cytotoxic species. Both genetic mutations and chronic exposure to neurotoxins increase αS aggregation and intracellular reactive oxygen species (ROS), leading to mitochondrial dysfunction and oxidative damage in PD cell models.ResultsHere we show that curcumin can alleviate αS-induced toxicity, reduce ROS levels and protect cells against apoptosis. We also show that both intracellular overexpression of αS and extracellular addition of oligomeric αS increase ROS which induces apoptosis, suggesting that aggregated αS may induce similar toxic effects whether it is generated intra- or extracellulary.ConclusionsSince curcumin is a natural food pigment that can cross the blood brain barrier and has widespread medicinal uses, it has potential therapeutic value for treating PD and other neurodegenerative disorders.

【 授权许可】

Unknown   
© Wang et al; licensee BioMed Central Ltd. 2010. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.