Prognosis and ICU outcome of systemic vasculitis

BMC Anesthesiology

Research Article

Boris Jung¹  Olivier Jonquet²  Philippe Corne²  Patrice Befort²  Kada Klouche³  Christian Bengler⁴  Thomas Filleron⁵ 

[1] Department of Anesthesia and Intensive care, Saint Eloi University Hospital, Montpellier, France;Department of Intensive Care Unit, Gui de Chauliac University Hospital, Montpellier, France;Department of Intensive Care Unit, Lapeyronie University Hospital, 191 Avenue du Doyen G. Giraud, 34090, Montpellier, France;Department of Intensive Care, University Hospital, Place Professeur Robert Debré, Nîmes, France;Statistics Claudius Regaud Institute, 20-24 rue du Pont Saint Pierre, Toulouse, France;

关键词: Vasculitis;    Outcome;    Mortality;    Intensive care unit;    BVAS;   

DOI  :  10.1186/1471-2253-13-27

 received in 2012-11-08, accepted in 2013-09-24,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundSystemic vasculitis may cause life threatening complications requiring admission to an intensive care unit (ICU). The aim of this study was to evaluate outcomes of systemic vasculitis patients admitted to the ICU and to identify prognosis factors.MethodsDuring a ten-year period, records of 31 adult patients with systemic vasculitis admitted to ICUs (median age: 63 y.o, sex ratio M/F: 21/10, SAPS II: 40) were reviewed including clinical and biological parameters, use of mechanical ventilation, catecholamine or/and dialysis support. Mortality was assessed and data were analyzed to identify predictive factors of outcome.ResultsCauses of ICU admissions were active manifestation of vasculitis (n = 19), septic shock (n = 8) and miscellaneous (n = 4). Sixteen patients (52%) died in ICU. By univariate analysis, mortality was associated with higher SOFA (p = 0.006) and SAPS II (p = 0.004) scores. The need for a catecholamine support or/and a renal replacement therapy, and the occurrence of an ARDS significantly worsen the prognosis. By multivariate analysis, only SAPS II (Odd ratio: 1.16, 95% CI [1.01; 1.33]) and BVAS scores (Odd ratio: 1.16, 95% CI = [1.01; 1.34]) were predictive of mortality.ConclusionThe mortality rate of severe vasculitis requiring an admission to ICU was high. High levels of SAPS II and BVAS scores at admission were predictive of mortality.

【 授权许可】

Unknown   
© Befort et al.; licensee BioMed Central Ltd. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.