Detection of occult paroxysmal atrial fibrilation by implantable long-term electrocardiographic monitoring in cryptogenic stroke and transient ischemic attack population: a study protocol for prospective matched cohort study

BMC Cardiovascular Disorders

Study Protocol

Jozef Hasilla¹  Pavel Vahala¹  Egon Kurča²  Štefan Sivák²  Luboš Urban³  Robert Hatala³  Miroslav Brozman⁴  Andrea Petrovičová⁴  Andrea Andrášová⁵  Peter Blaško⁵ 

[1] Clinic of Cardiology, Faculty Hospital, Constantine Philosopher University, Špitálska 6, 94901, Nitra, Slovak Republic;Clinic of Neurology, Jessenius Faculty of Medicine, Comenius University, Kollárova 2, 03659, Martin, Slovak Republic;Department of Arrhythmias and Cardiac Pacing, The National Institute of Cardiovascular Diseases, Pod Krásnou hôrkou 1, 83348, Bratislava, Slovak Republic;Department of Neurology, Faculty Hospital, Constantine Philosopher University, Špitálska 6, 94901, Nitra, Slovak Republic;Kardiocentrum Nitra s.r.o, Špitálska 1, 94901, Nitra, Slovak Republic;

关键词: Transient ischemic attack;    Cryptogenic stroke;    Atrial fibrillation;    Implantable loop recorder;    PITX2;    ZFHX3;   

DOI  :  10.1186/s12872-015-0160-8

 received in 2015-03-30, accepted in 2015-11-30,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundCardio-embolic etiology is the most frequently predicted cause of cryptogenic stroke/TIA. Detection of occult paroxysmal atrial fibrillation is crucial for selection of appropriate medication.MethodsEnrolment of eligible cryptogenic stroke and TIA patients began in 2014 and will continue until 2018. The patients undergo long-term (12 months) ECG monitoring (implantable loop recorder) and testing for PITX2 (chromosome 4q25) and ZFHX3 (chromosome 16q22) gene mutations. There will be an appropriate control group of age- and sex-matched healthy volunteers. To analyse the results descriptive statistics, statistical tests for group differences, and correlation analyses will be used.DiscussionIn our study we are focusing on a possible correlation between detection of atrial fibrillation by an implantable ECG recorder, and PITX2 and/or ZFHX3 gene mutations in cryptogenic stroke/TIA patients. A correlation could lead to implementation of this genomic approach to cryptogenic stroke/TIA diagnostics and management. The results will be published in 2018.Trial registrationClinicalTrials.gov: NCT02216370.

【 授权许可】

CC BY   
© Petrovičová et al. 2015