The Rivas Cohort Study: design and baseline characteristics of a Nicaraguan cohort

BMC Nephrology

Research Article

Melissa Fiore¹  Martha Mosco²  Hillary Paulsen³  Daniel Brooks⁴  Bricia Trejo⁵  Cassandra Parker⁶  Louis Fiore⁷  Matthew Lawlor⁸  Juan Jose Amador⁹  Rulan Parekh^1,10  Zachary Ernstberger^1,11  Ryan Ferguson^1,12  Elyse Sullivan^1,13  Amos Lichtman^1,14  Madeline Fiore^1,15  Keriann Nobil^1,16  Kailey Minnings^1,17  Sarah Leatherman^1,18  James Kaufman^1,19  Eric Kerns^2,20 

[1] Athena Health, 311 Arsenal Street, 02472, Watertown, MA, USA;Athena Health, 18 Parker Street, 02138, Cambridge, MA, USA;Beth Israel Deaconess Medical Center, 330 Brookline Ave, 02215, Boston, MA, USA;Beth Israel Deaconess Medical Center, 16 Oak Manor Dr. Barrington, 02806, Barrington, RI, USA;Boston Children’s Hospital, 401 Park Dr., 6th Floor, Landmark Center, 02115, Boston, MA, USA;Boston Children’s Hospital, 12 Greenway Ct. Apt. 3, 02446, Brookline, MA, USA;Boston University School of Public Health, 715 Albany Street, T317E, 02118, Boston, MA, USA;Boston University School of Public Health, 801 Massachusetts Avenue 4th Floor, 02118, Boston, MA, USA;Boston University School of Public Health, 60 Parkway Road, 02460, Newton, MA, USA;Boston University Schools of Medicine and Public Health, 160 E Berkeley St. Apt 304, 02118, Boston, MA, USA;Boston University Schools of Medicine and Public Health, 72 E. Concord Street, 02118, Boston, MA, USA;Boston University Schools of Medicine and Public Health, 72 E. Concord Street, 02118, Boston, MA, USA;Boston University Schools of Medicine and Public Health, 255 Newbury St 1R, 02116, Boston, MA, USA;Boston University, 715 Albany St., Talbot 3 East, 02118, Boston, MA, USA;Hospital for Sick Children, University Health Network and University of Toronto, 555 University Ave, M5G1X8, Toronto, ON, Canada;Indiana University School of Medicine, 340 West 10th Street, Suite 6200, 46202, Indianapolis, IN, USA;Indiana University School of Medicine, 1547 N. College Ave, 46202, Indianapolis, IN, USA;Massachusetts Veterans Epidemiology Research and Information Center Health, 150 South Huntington Avenue, 02130, Boston, MA, USA;Northeastern University, 350 Huntington Ave, 02115, Boston, MA, USA;Northeastern University, 255 Newbury Street, Apr1R, 02116, Boston, MA, USA;UMass Medical School, 55 N Lake Ave, 01604, Worcester, MA, USA;UMass Medical School, 60 Parkway Rd., 02460, Newton, MA, USA;UMass Medical School, 55 N Lake Ave, Chestnut St. Apt 21, MA 01604 34, Worcester, UK;UMass Medical School, 55 N Lake Ave, Chestnut St. Apt 21, MA 01609, Worcester, UK;University of Massachusetts Medical School, 55 N. Lake Ave, 01605, Worcester, MA, USA;University of Massachusetts Medical School, 285 Plantation St Apt 522, 01604, Worcester, MA, USA;University of Toronto Faculty of Medicine, 1 King’s College Circle, M5S 1A8, Toronto, ON, Canada;VA Boston Healthcare System, 150 South Huntington Ave, 02130, Boston, MA, USA;VA New York Healthcare System, 423 East 23rd Street, 10010, New York, NY, USA;Warren Alpert Medical School of Brown University, 593 Eddy Street, APC 9, 02903, Providence, RI, USA;

关键词: Cohort studies;    Nicaragua;    Central America;    Renal insufficiency;    Public health;    Public health surveillance;    Data collection;    Baseline Survey;    Creatinine;   

DOI  :  10.1186/s12882-016-0320-9

 received in 2015-06-16, accepted in 2016-07-20,  发布年份 2016

来源: Springer

【 摘 要 】

BackgroundA lack of advanced healthcare information systems and validated scientific cohorts in Nicaragua makes it difficult to estimate disease prevalences and other public health statistics. Although there is concern of an “epidemic” of chronic kidney disease (CKD) in this country, statistics regarding its magnitude are derived from only a small number of non-representative studies. Budgetary constraints and the logistical problems of maintaining a study cohort make longitudinal studies difficult. The Rivas Cohort was created to measure disease burden of CKD and other public health priorities in the Department of Rivas, Nicaragua. Using primarily volunteer research students and technologic innovation including GPS, digital photography and point of care biochemical analysis, the ability to establish a longitudinal chronic disease cohort is demonstrated.MethodsSubjects were recruited from consecutive adjacent households in thirty-two randomly selected communities in the ten municipalities that comprise the Department of Rivas in southern Pacific coastal Nicaragua. The study was conducted in two phases. In the first phase, subjects were enrolled into the cohort and consented for future re-contact. In Phase II, conducted two years later, attempts were made to re-contact 400 of these subjects for additional data collection. Demographic, lifestyle, occupational, exposure and health data was collected for both phases of the study. Blood and urine testing and height, weight and blood pressure measurements were also performed. GPS coordinates of homes were recorded and maps of remote communities created.ResultsOf 1397 adults living in 533 households approached for participation a total of 1242 (89 %) were enrolled in the cohort. The median age is 41 years and 43 % are male, demographics in agreement with Nicaraguan census data for the Department of Rivas. During Phase II we attempted to re-contact 400 subjects for a follow-up study of CKD. It was possible to re-contact 84 % of these participants and of those re-contacted 95 % agreed to participate in the follow-up study. Of subjects that were not successfully re-contacted the majority had either moved (32) or were not at home (22) at the time of the study team visits.ConclusionThe Rivas Cohort Study enrolled a representative sample of 1242 adults living in the Department of Rivas, Nicaragua. The high re-contact and participation rates at two years suggests that the cohort is suitable for long-term studies and presents opportunities for investigations of disease prevalence, incidence, treatment and other public health matters. GPS coordinates and maps are available for future researchers who wish to use the cohort for additional studies.

【 授权许可】

CC BY   
© Minnings et al. 2016