Volume expansion of periaqueductal gray in episodic migraine: a pilot MRI structural imaging study

The Journal of Headache and Pain

Research Article

Xiaoyan Chen¹  Shengyuan Yu¹  Shuangfeng Liu²  Lin Ma²  Zhiye Chen³  Mengqi Liu⁴ 

[1] Department of Neurology, Chinese PLA General Hospital, Fuxing Road 28, 100853, Beijing, China;Department of Radiology, Chinese PLA General Hospital, Fuxing Road 28, 100853, Beijing, China;Department of Radiology, Chinese PLA General Hospital, Fuxing Road 28, 100853, Beijing, China;Department of Neurology, Chinese PLA General Hospital, Fuxing Road 28, 100853, Beijing, China;Department of Radiology, Hainan Branch of Chinese PLA General Hospital, 572013, Sanya, China;Department of Radiology, Chinese PLA General Hospital, Fuxing Road 28, 100853, Beijing, China;Department of Radiology, Hainan Branch of Chinese PLA General Hospital, 572013, Sanya, China;

关键词: Chronic migraine;    Episodic migraine;    Periaqueductal gray;    Magnetic resonance imaging;    Volume measurement;   

DOI  :  10.1186/s10194-017-0797-z

 received in 2017-07-11, accepted in 2017-08-08,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundThe periaqueductal gray (PAG) dysfunction was recognized in migraine, and the nonspecific PAG lesions were also observed in episodic migraine (EM) recently. However, the PAG volume change was not totally detected in EM up to now. Herein, the aim of this study was to investigate altered PAG volume in EM patients based on high resolution brain structural image.MethodsThe brain structural images were obtained from 18 normal controls (NC), 18 EM patients and 16 chronic migraine (CM) on 3.0 T MR system. PAG template was created based on the ICBM152 gray matter template using MRIcron, and the individual PAG was created by applying the deformation field to the PAG template after structural image segment. One-way analysis of covariance, partial correlation analysis and Receiver operating characteristics (ROC) curve were applied.ResultsEM had a larger PAG volume (0.35 ± 0.02 ml) than that (0.32 ± 0.02 ml) of NC (P = 0.017). The PAG volume of CM (0.33 ± 0.02 ml) was negatively related to the VAS score (P = 0.03). ROC analysis demonstrated that PAG volume has higher diagnostic efficacy (AUC, 0.731; Sensitivity, 0.556; Specificity, 0.889) for NC vs. EM compared with that NC vs. CM (AUC, 0.634; Sensitivity, 0.438; Specificity, 0.833) and EM vs. CM (AUC, 0.618; Sensitivity, 0.813; Specificity, 0.556).ConclusionPAG volume expansion may be the direct impairment evidence on the brain in EM, and could be considered as a diagnostic and evaluated imaging biomarker in migraine.

【 授权许可】

CC BY   
© The Author(s). 2017