Does sumatriptan cross the blood–brain barrier in animals and man?

The Journal of Headache and Pain

Review Article

Peer Carsten Tfelt-Hansen¹ 

[1] Department of Neurology, Faculty of Health Sciences, Danish Headache Center, Glostrup Hospital, University of Copenhagen, Glostrup, 2600, Copenhagen, Denmark;

关键词: Blood–brain barrier;    Sumatriptan;    Migraine;    CNS;    Animal studies;    Human studies;   

DOI  :  10.1007/s10194-009-0170-y

 received in 2009-08-24, accepted in 2009-10-27,  发布年份 2009

来源: Springer

【 摘 要 】

Sumatriptan, a relatively hydrophilic triptan, based on several animal studies has been regarded to be unable to cross the blood–brain barrier (BBB). In more recent animal studies there are strong indications that sumatriptan to some extent can cross the BBB. The CNS adverse events of sumatriptan in migraine patients and normal volunteers also indicate a more general effect of sumatriptan on CNS indicating that the drug can cross the BBB in man. It has been discussed whether a defect in the BBB during migraine attacks could be responsible for a possible central effect of sumatriptan in migraine. This review suggests that there is no need for a breakdown in the BBB to occur in order to explain a possible central CNS effect of sumatriptan.

【 授权许可】

Unknown   
© Springer-Verlag 2009