Evidence for an association between migraine and the hypocretin receptor 1 gene

The Journal of Headache and Pain

Original

Luigi Rocco Picci¹  Luca Ostacoli¹  Laura Giobbe²  Elisa Rubino²  Lorenzo Pinessi²  Pierpaola Fenoglio²  Salvatore Gallone²  Innocenzo Rainero² 

[1] Mental Health Department, San Luigi Gonzaga Hospital, University of Turin, Orbassano, Italy;Neurology II, Department of Neuroscience, University of Torino, Via Cherasco 15, 10126, Turin, Italy;

关键词: Migraine without aura;    Migraine with aura;    Hypocretin receptor 1;    Hypocretins;    Genetic association studies;   

DOI  :  10.1007/s10194-011-0314-8

 received in 2010-09-02, accepted in 2010-12-12,  发布年份 2011

来源: Springer

【 摘 要 】

The aim of our study was to investigate whether genetic variants in the hypocretin receptor 1 (HCRTR1) gene could modify the occurrence and the clinical features of migraine. Using a case–control strategy we genotyped 384 migraine patients and 259 controls for three SNPs in the HCRTR1 gene. Genotypic and allelic frequencies of the rs2271933 non-synonymous polymorphism resulted different (χ2 = 9.872, p = 0.007; χ2 = 8.108, p = 0.004) between migraineurs and controls. The carriage of the A allele was associated with an increased migraine risk (OR 1.42, 95% CI 1.11–1.81). When we divided the migraine patients into different subgroups, the difference reached the level of statistical significance only in migraine without aura. The different genotypes had no significant effect on the examined clinical characteristics of the disease. In conclusion, our data supports the hypothesis that the HCRTR1 gene could represent a genetic susceptibility factor for migraine without aura and suggests that the hypocretin system may have a role in the pathophysiology of migraine.

【 授权许可】

CC BY   
© The Author(s) 2011