Case-control study of ADARB1 and ADARB2 gene variants in migraine

The Journal of Headache and Pain

Research Article

Larisa M Haupt¹  Heidi G Sutherland¹  Lyn R Griffiths¹  Astrid J Rodriguez-Acevedo¹  Elhame Khlifi¹  Bridget Maher²  Claudia F Gasparini³ 

[1] Genomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Musk Ave, 4059, Kelvin Grove, QLD, Australia;Genomics Research Centre, Institute of Health and Biomedical Innovation, Queensland University of Technology, Musk Ave, 4059, Kelvin Grove, QLD, Australia;UCL Institute of Neurology, Department of Clinical and Experimental Epilepsy, Queen Square, WC1N 3BG, London, UK;Menzies Health Institute Queensland, Griffith University Gold Coast, Parklands Drive, 4222, Southport, QLD, Australia;

关键词: Migraine;    Migraine with aura;    Migraine without aura;    RNA editing;    pGWAS;    Norfolk Island;    ADARB1;    ADARB2;    Headache;   

DOI  :  10.1186/s10194-015-0511-y

 received in 2014-12-23, accepted in 2015-03-06,  发布年份 2015

来源: Springer

【 摘 要 】

BackgroundMigraine causes crippling attacks of severe head pain along with associated nausea, vomiting, photophobia and/or phonophobia. The aim of this study was to investigate single nucleotide polymorphisms (SNPs) in the adenosine deaminase, RNA-specific, B1 (ADARB1) and adenosine deaminase, RNA specific, B2 (ADARB2) genes in an Australian case–control Caucasian population for association with migraine. Both candidate genes are highly expressed in the central nervous system and fit criteria for migraine neuropathology. SNPs in the ADARB2 gene were previously found to be positively associated with migraine in a pedigree-based genome wide association study using the genetic isolate of Norfolk Island, Australia. The ADARB1 gene was also chosen for investigation due to its important function in editing neurotransmitter receptor transcripts.MethodsFour SNPs in ADARB1 and nine in ADARB2 were selected by inspecting blocks of linkage disequilibrium in Haploview for genotyping using either TaqMan or Sequenom assays. These SNPs were genotyped in two-hundred and ninety one patients who satisfied the International Classification of Headache Disorders-II 2004 diagnostic criteria for migraine, and three-hundred and fourteen controls, and PLINK was used for association testing.ResultsChi-square analysis found no significant association between any of the SNPs tested in the ADARB1 and ADARB2 genes in this study and the occurrence of migraine.ConclusionsIn contrast to findings that SNPs in the ADARB2 gene were positively associated with migraine in the Norfolk Island population, we find no evidence to support the involvement of RNA editing genes in migraine susceptibility in an Australian Caucasian population.

【 授权许可】

Unknown   
© Gaspirini et al.; licensee Springer. 2015. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.