Polymorphisms of the SCN1A gene in children and adolescents with primary headache and idiopathic or cryptogenic epilepsy: is there a linkage?

The Journal of Headache and Pain

Original

Clementina Boniver¹  Pier Antonio Battistella¹  Stefano Sartori¹  Irene Toldo¹  Pasquale Montagna²  Alberto Casarin³  Maurizio Clementi³  Alice Bruson³  Leonardo Salviati³ 

[1] Child Neurology Unit, Department of Pediatrics, University of Padua, Via Giustiniani, 3, 35128, Padua, Italy;Department of Neurological Sciences, University of Bologna, Bologna, Italy;Genetic Unit, Department of Pediatrics, University of Padua, Padua, Italy;

关键词: Migraine;    Epilepsy;    Comorbidity;    SCN1A;    Children;   

DOI  :  10.1007/s10194-011-0359-8

 received in 2011-03-15, accepted in 2011-06-07,  发布年份 2011

来源: Springer

【 摘 要 】

The purpose of this study was to evaluate the distribution of the polymorphisms of the SCN1A gene in a series of children and adolescents with primary headache and idiopathic or cryptogenic epilepsy compared to controls. Five non-synonymous exonic polymorphisms (1748A > T, 2656T > C, 3199A > G, 5771G > A, 5864T > C) of the SCN1A gene were selected and their genotyping was performed, by high resolution melting (HRM), in 49 cases and 100 controls. We found that among the five polymorphisms, only 3199A > G was a true polymorphism. We did not find a statistically significant difference between distribution of 3199A > G genotypes between cases and controls. We excluded the role of the SCN1A gene in the pathogenesis of comorbidity between headache (especially migraine) and epilepsy. The SCN1A gene is a major gene in different epilepsies and epilepsy syndromes; the HRM could be the new methodology, more rapid and efficacious, for molecular analysis of the SCN1A gene.

【 授权许可】

CC BY   
© The Author(s) 2011