Cardiovascular disease risk in women with migraine

The Journal of Headache and Pain

Research Article

Ingrid D Schweigert Perry¹  Alexandre da Silveira Perla²  Fernanda Camboim Rockett³  Márcia L Fagundes Chaves⁴ 

[1] Food and Nutrition Research Centre - Hospital de Clínicas de Porto Alegre/Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil;Department of Internal Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil;Neurology Service - Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil;Postgraduate Program in Medicine: Medical Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil;Food and Nutrition Research Centre - Hospital de Clínicas de Porto Alegre/Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil;Postgraduate Program in Medicine: Medical Sciences, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil;Neurology Service - Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil;Department of Internal Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil;

关键词: Migraine;    Cardiovascular disease;    Cardiovascular risk;    C-reactive protein;    Depression;    Sleep disturbance;   

DOI  :  10.1186/1129-2377-14-75

 received in 2013-06-20, accepted in 2013-09-03,  发布年份 2013

来源: Springer

【 摘 要 】

BackgroundStudies suggest a higher prevalence of unfavourable cardiovascular risk factors amongst migraineurs, but results have been conflicting. The aim of this study was to investigate traditional and newly recognized risk factors as well as other surrogate markers of cardiovascular risk in obese and normal weight women with migraine.MethodsFifty-nine adult female probands participated in this case–control study. The sample was divided into normal weight and obese migraineurs and age- and body mass index-matched control groups. The following cardiovascular risk factors were analyzed: serum levels of lipids, fasting glucose, and insulin; insulin resistance; blood pressure; smoking (categorized as current, past or never); Framingham 10-year risk of general cardiovascular disease score; C-reactive protein; family history of cardiovascular disease; physical activity; sleep disturbances; depression; and bioelectrical impedance phase angle. The means of continuous variables were compared using Student’s t- test for independent samples or the Mann–Whitney U- test (for 2 groups) and ANOVA or the Kruskal-Wallis test (for 4 groups) depending on the distribution of data.ResultsAll migraineurs were sedentary irrespective of nutritional status. Migraineurs had higher depression scores and shorter sleep duration, and obese migraineurs, in particular, had worse sleep quality scores. Insulin resistance and insulinaemia were associated with obesity, and obese migraineurs had lower HDL-c than normal weight controls and migraineurs. Also, the Framingham risk score was higher in obese migraineurs.ConclusionThese findings suggest that female migraineurs experience marked inactivity, depression, and some sleep disturbance, that higher insulin resistance and insulinaemia are related to obesity, and that obesity and migraine probably exert overlapping effects on HDL-c levels and Framingham 10-year cardiovascular risk.

【 授权许可】

CC BY   
© Rockett et al.; licensee Springer. 2013. This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.