C-reactive protein in traditional melanesians on Kitava

BMC Cardiovascular Disorders

Pedro Carrera-Bastos¹  Kristina Sundquist¹  Maelán Fontes-Villalba¹  Tommy Jönsson¹  Michael Gurven²  Lennart Råstam³  Yvonne Granfeldt⁴  Frits A. J. Muskiet⁵  Torbjörn Åkerfeldt⁶  Yinon Shapira⁷  Johan Frostegård⁸  Ulf Lindblad⁹  Yehuda Shoenfeld^1,10 

[1] Center for Primary Health Care Research, Lund University/Region Skåne, Skåne University Hospital;Department of Anthropology, University of California;Department of Clinical Sciences, Community Medicine, Lund University;Department of Food Technology, Engineering and Nutrition, Lund University;Department of Laboratory Medicine, University Medical Centre Groningen, University of Groningen;Department of Medical Sciences, Uppsala University, Uppsala University Hospital;Department of Ophthalmology, Rambam Health Care Campus;IMM, Unit of Immunology and Chronic Disease, Karolinska Institutet;School of Public Health and Community Medicine, University of Gothenburg;Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center (Affiliated To Tel-Aviv University);

关键词: C-reactive protein;    Cardiovascular risk;    Traditional melanesians;   

DOI  :  10.1186/s12872-020-01812-7

来源: DOAJ

【 摘 要 】

Abstract Background Population-based levels of the chronic low-grade systemic inflammation biomarker, C-reactive protein (CRP), vary widely among traditional populations, despite their apparent absence of chronic conditions associated with chronic low-grade systemic inflammation, such as type 2 diabetes, metabolic syndrome and cardiovascular disease. We have previously reported an apparent absence of aforementioned conditions amongst the traditional Melanesian horticulturalists of Kitava, Trobriand Islands, Papua New Guinea. Our objective in this study was to clarify associations between chronic low-grade systemic inflammation and chronic cardiometabolic conditions by measuring CRP in a Kitava population sample. For comparison purposes, CRP was also measured in Swedish controls matched for age and gender. Methods Fasting levels of serum CRP were measured cross-sectionally in ≥ 40-year-old Kitavans (N = 79) and Swedish controls (N = 83). Results CRP was lower for Kitavans compared to Swedish controls (Mdn 0.5 mg/L range 0.1—48 mg/L and Mdn 1.1 mg/L range 0.1—33 mg/L, respectively, r = .18 p = .02). Among Kitavans, there were small negative associations between lnCRP for CRP values < 10 and total, low-density lipoprotein (LDL) and non-high-density lipoprotein (non-HDL) cholesterol. Among Swedish controls, associations of lnCRP for CRP values < 10 were medium positive with weight, body mass index, waist circumference, hip circumference and waist-hip ratio and low positive with triglyceride, total cholesterol-HDL cholesterol ratio, triglyceride-HDL cholesterol ratio and serum insulin. Conclusions Chronic low-grade systemic inflammation, measured as CRP, was lower among Kitavans compared to Swedish controls, indicating a lower and average cardiovascular risk, respectively, for these populations.

【 授权许可】

Unknown