The relationship between right-to-left shunt and brain white matter lesions in Japanese patients with migraine: a single center study

The Journal of Headache and Pain

Short Report

Shiho Suzuki¹  Keisuke Suzuki¹  Ryotaro Takashima¹  Koichi Hirata¹  Ayano Suzuki²  Akio Iwasaki²  Hidehiro Takekawa³ 

[1] Department of Neurology, Dokkyo Medical University, Tochigi, Japan;Stroke Division, Department of Neurology, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Shimotsuga-gun, 322-0293, Tochigi, Japan;Stroke Division, Department of Neurology, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Shimotsuga-gun, 322-0293, Tochigi, Japan;Center of Medical Ultrasonics, Dokkyo Medical University, Tochigi, Japan;

关键词: Migraine;    Right-to-left shunt;    Brain white matter lesions;    Patent foramen ovale;    Pulmonary arteriovenous malformations;    Transcranial ultrasonography;   

DOI  :  10.1186/s10194-016-0714-x

 received in 2016-11-06, accepted in 2016-12-12,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundThere may be a link between right-to-left shunt (RLs) and brain white matter lesions (WMLs) in patients with migraine. In this study, we assessed the relationship between WMLs and RLs in Japanese migraine patients.MethodsA total of 107 consecutive patients with migraine with (MA) and without aura (MWOA) were included in this study. Contrast transcranial Doppler ultrasound was used to detect RLs. WMLs were graded using brain magnetic resonance imaging based on well-established criteria.FindingsThe prevalence of RLs was significantly increased in the WMLs positive group (n = 24) compared with the WMLs negative group (n = 83) (75.0% vs. 47.0%, p = 0.015). In prevalence of WMLs between MA and MWOA patients, there were no statistical differences (p = 0.410). Logistic regression analysis adjusted by age and disease duration of migraine identified an RLs-positive status as the sole determinant for the presence of WMLs (OR = 6.15; 95% CI 1.82–20.8; p = 0.003)ConclusionOur study suggests a possible link between RLs and WMLs in Japanese patients with migraine.

【 授权许可】

CC BY   
© The Author(s). 2017