Migraine and percutaneous patent foramen ovale closure: a systematic review and meta-analysis

BMC Cardiovascular Disorders

Research Article

Jun Lv¹  Guo-Gang Luo¹  Yu-Jie Shi²  Xing-Ting Han³ 

[1] Department of Neurology, The First Affiliated Hospital of Xi’an Jiaotong University, 277 Yanta West Road, 710061, Xi’an, Shaanxi, China;Department of Neurology, Xi’an Jiaotong University, Xi’an, China;Department of Stomatology, Xi’an Jiaotong University, Xi’an, China;

关键词: Migraine;    Migraine with aura;    Patent foramen ovale;    Percutaneous patent foramen ovale closure;    Right-to-left shunt;   

DOI  :  10.1186/s12872-017-0644-9

 received in 2017-04-24, accepted in 2017-07-24,  发布年份 2017

来源: Springer

【 摘 要 】

BackgroundThe association between patent foramen ovale (PFO) and migraine with aura (MA) is well established. However, the benefits of PFO closure are less certain in patients with migraine without aura (MwoA).MethodsWe systematically searched Pubmed for pertinent clinical studies published from January 2000 to July 2015. The primary end-point was the elimination or significant improvement of migraine symptoms after PFO closure.ResultsUpon screening an initial list of 315 publications, we identified eight studies that included 546 patients. Overall, our analysis indicated a significant improvement of migraine in 81% of MA cases compared to only 63% of MwoA cases. The summary odds ratio was 2.5 (95% confidence interval 1.09–5.73), and the benefits of PFO closure were significantly greater for patients with MA compared to patients with MwoA (P = 0.03).ConclusionsThe presence of aura provides a reference standard for the clinical selection of patients with migraine for PFO closure intervention.

【 授权许可】

CC BY   
© The Author(s). 2017