Association of soluble suppression of tumorigenicity 2 protein with new-onset atrial fibrillation in patients with acute ST-segment elevation myocardial infarction undergoing primary PCI

Frontiers in Cardiovascular Medicine

Cardiovascular Medicine

Ting-ting Zhao¹  Yi-bo Yang¹  Yong Wang²  Xiao-yang Pei²  Tian-jiao Pan³ 

[1] Department of Cardiology, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, China;Department of Cardiology, Shenzhen Luohu Hospital Group Luohu People’s Hospital (The Third Affiliated Hospital of Shenzhen University), Shenzhen, China;Department of Day-Surgery, The First Affiliated Hospital of China Medical University, Shenyang, China;

关键词: soluble ST2;    new-onset atrial fibrillation;    acute ST-segment elevation myocardial infarction;    PCI;    predictor;   

DOI  :  10.3389/fcvm.2023.1207219

 received in 2023-04-17, accepted in 2023-09-06,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundPrevious studies have indicated that the soluble suppression of tumorigenicity 2 protein (sST2) is associated with new-onset atrial fibrillation (NOAF) in patients diagnosed with coronary artery disease (CAD). However, the predictive value of sST2 in patients with acute ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI) has not been well studied.MethodsA total of 580 patients with STEMI undergoing primary PCI were consecutively recruited between January 2021 and January 2023. These patients were then categorized into two groups: the NOAF group and the no NOAF groups based on the presence of NOAF during admission. The concentration of sST2 in blood samples was measured in all patients. The clinical data from the two groups were prospectively analyzed to investigate the predictive factors of NOAF in patients with STEMI undergoing primary PCI.ResultsA total of 41 (7.1%) patients developed NOAF. The presence of NOAF has been found to be associated with various factors, including age, diabetes mellitus, hypertension, the left atrial (LA) diameter, N-terminal pro-brain natriuretic peptide, C-reactive protein (CRP), sST2, a Killip class of ≥2, and a final TIMI flow grade of <3. After including multiple factors, it was observed that LA diameter, CRP, sST2, a Killip class of ≥2, and a final TIMI flow grade of <3 remained significant risk factors for developing NOAF. The receiver operating characteristic (ROC) curve showed the following findings: (1) when the LA diameter exceeded 38.5 mm, the sensitivity and specificity values were observed to be 67.2% and 68.2%, respectively, and the area under the ROC curve (AUC) was 0.683 [95% confidence interval (CI): 0.545–0.732; p = 0.003]; (2) when the CRP level exceeded 8.59, the sensitivity and specificity values were observed to be 68.6% and 69.2%, respectively, and the AUC was 0.713 (95% CI: 0.621–0.778; p < 0.001); and (3) when the sST2 value exceeded 53.3, the sensitivity and specificity values were 79.2% and 68.7%, respectively, and the AUC was 0.799 (95% CI: 0.675–0.865; p < 0.001).ConclusionsST2 has been identified as an independent predictor of NOAF in patients with STEMI undergoing PCI.

【 授权许可】

Unknown   
© 2023 Zhao, Pan, Yang, Pei and Wang.