Causality of anti-Helicobacter pylori IgG levels on myocardial infarction and potential pathogenesis: a Mendelian randomization study

Frontiers in Microbiology

Microbiology

Yingbo Liu¹  Mei Xue²  Zhimiao Wang²  Zhenxing Xu²  Xinran Li²  Ye Wang²  Qiubo Wang³ 

[1] Center for Reproductive Medicine, Shandong University, Jinan, China;Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Jinan, China;Department of Cardiology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Medicine and Health Key Laboratory of Cardiac Electrophysiology and Arrhythmia, Jinan, China;Department of Cardiology, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Medicine and Health Key Laboratory of Cardiac Electrophysiology and Arrhythmia, Jinan, China;Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China;

关键词: Helicobacter pylori;    myocardial infarction;    HDL cholesterol;    causal association;    Mendelian randomization;   

DOI  :  10.3389/fmicb.2023.1259579

 received in 2023-07-16, accepted in 2023-08-28,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundPrevious observational studies have shown that a potential relationship between anti-Helicobacter pylori (H. pylori) IgG levels and Myocardial Infarction (MI). Nevertheless, the evidence for the causal inferences remains disputable. To further clarify the relationship between anti-H. pylori IgG levels and MI and explore its pathogenesis, we conducted a Mendelian randomization (MR) analysis.MethodsIn this study, we used two-sample Mendelian Randomization (MR) to assess the causality of anti-H. pylori IgG levels on MI and potential pathogenesis, 12 single nucleotide polymorphisms (SNPs) related to anti-H. pylori IgG levels were obtained from the European Bioinformatics Institute (EBI). Summary data from a large-scale GWAS meta-analysis of MI was utilized as the outcome dataset. Summary data of mediators was obtained from the FinnGen database, the UK Biobank, the EBI database, MRC-IEU database, the International Consortium of Blood Pressure, the Consortium of Within family GWAS. Inverse variance weighted (IVW) analysis under the fixed effect model was identified as our main method. To ensure the reliability of the findings, many sensitivity analyses were performed.ResultsOur study revealed that increases of anti-H. pylori IgG levels were significantly related to an increased risk of MI (OR, 1.104; 95% CI,1.042–1.169; p = 7.084 × 10−4) and decreases in HDL cholesterol levels (β, −0.016; 95% CI, −0.026 to −0.006; p = 2.02 × 10−3). In addition, there was no heterogeneity or pleiotropy in our findings.ConclusionThis two-sample MR analysis revealed the causality of anti-H. pylori IgG levels on MI, which might be explained by lower HDL cholesterol levels. Further research is needed to clarify the results.

【 授权许可】

Unknown   
Copyright © 2023 Wang, Liu, Xu, Wang, Xue, Li and Wang.