Case Report: Metagenomic next-generation sequencing applied in diagnosing psittacosis caused by Chlamydia psittaci infection

Frontiers in Cellular and Infection Microbiology

Cellular and Infection Microbiology

Wan Xu¹  Binghua Zhu¹  Qing Wang¹  Qian Wang¹  Rong Fang¹  Lin Li¹  Qingqing Cai²  Xiaoli Yi² 

[1] Department of Emergency Internal Medicine, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China;Genoxor Medical Science and Technology Inc., Shanghai, China;

关键词: psittacosis;    Chlamydia psittaci;    infection;    diagnosis;    mNGS;   

DOI  :  10.3389/fcimb.2023.1249225

 received in 2023-06-30, accepted in 2023-08-29,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundChlamydia psittaci is the causative agent of psittacosis in humans, while its rapid identification is hampered due to the lack of specificity of laboratory testing methods.Case presentationThis study reports four cases of C. psittaci infection after contact with a domestic parrot, all belonging to the same family. Common manifestations like fever, cough, headache, nausea, and hypodynamia appeared in the patients. Metagenomic next-generation sequencing (mNGS) aided the etiological diagnosis of psittacosis, revealing 58318 and 7 sequence reads corresponding to C. psittaci in two cases. The detected C. psittaci was typed as ST100001 in the Multilocus-sequence typing (MLST) system, a novel strain initially reported. Based on the results of pathogenic identification by mNGS, the four patients were individually, treated with different antibiotics, and discharged with favorable outcomes.ConclusionIn diagnosing psittacosis caused by a rare C. psittaci agent, mNGS provides rapid etiological identification, contributing to targeted antibiotic therapy and favorable outcomes. This study also reminds clinicians to raise awareness of psittacosis when encountering family members with a fever of unknown origin.

【 授权许可】

Unknown   
Copyright © 2023 Xu, Wang, Li, Zhu, Cai, Yi, Fang and Wang