The role of prostate-specific antigen in the osteoblastic bone metastasis of prostate cancer: a literature review

Frontiers in Oncology

Oncology

Peng Jiang¹  Xu Zhang¹  Chaojun Wang¹ 

[1]Department of Urology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China

关键词: prostate-specific antigen;    osteoblastic bone metastasis;    osteoclast;    osteoblast;    insulin-like growth factor;    transforming growth factor β2;    parathyroid hormone-related protein;   

DOI  :  10.3389/fonc.2023.1127637

 received in 2022-12-19, accepted in 2023-08-23,  发布年份 2023

来源: Frontiers

【 摘 要 】

Prostate cancer is the only human malignancy that generates predominantly osteoblastic bone metastases, and osteoblastic bone metastases account for more than 90% of osseous metastases of prostate cancer. Prostate-specific antigen (PSA) plays an important role in the osteoblastic bone metastasis of prostate cancer, which can promote osteomimicry of prostate cancer cells, suppress osteoclast differentiation, and facilitate osteoblast proliferation and activation at metastatic sites. In the meantime, it can activate osteogenic factors, including insulin-like growth factor, transforming growth factor β2 and urokinase-type plasminogen activator, and meanwhile suppress osteolytic factors such as parathyroid hormone-related protein. To recapitulate, PSA plays a significant role in the osteoblastic predominance of prostate cancer bone metastasis and bone remodeling by regulating multiple cells and factors involved in osseous metastasis.

【 授权许可】

Unknown   
Copyright © 2023 Zhang, Jiang and Wang