In-silico enhanced animal study of pulmonary artery pressure sensors: assessing hemodynamics using computational fluid dynamics

Frontiers in Cardiovascular Medicine

Cardiovascular Medicine

Tobias Jochum¹  Jan Romberg¹  Sonja Meine¹  Livia van Gijzen¹  Andreas Arndt¹  Jan Brüning²  Adriano Schlief²  Titus Kuehne²  Pavlo Yevtushenko²  Leonid Goubergrits³ 

[1] Biotronik, Berlin, Germany;Institute of Computer-assisted Cardiovascular Medicine, Deutsches Herzzentrum der Charité, Berlin, Germany;Charité - Universitätsmedizin Berlin, Berlin, Germany;Institute of Computer-assisted Cardiovascular Medicine, Deutsches Herzzentrum der Charité, Berlin, Germany;Charité - Universitätsmedizin Berlin, Berlin, Germany;Einstein Center Digital Future, Berlin, Germany;

关键词: heart failure;    pulmonary artery;    pressure sensor;    computational fluid dynamics;    wall shear stress;    oscillating shear index;    computed tomography;    porcine animal model;   

DOI  :  10.3389/fcvm.2023.1193209

 received in 2023-03-24, accepted in 2023-08-17,  发布年份 2023

来源: Frontiers

【 摘 要 】

To assess whether in-silico models can be used to predict the risk of thrombus formation in pulmonary artery pressure sensors (PAPS), a chronic animal study using pigs was conducted. Computed tomography (CT) data was acquired before and immediately after implantation, as well as one and three months after the implantation. Devices were implanted into 10 pigs, each one in the left and right pulmonary artery (PA), to reduce the required number of animal experiments. The implantation procedure aimed at facilitating optimal and non-optimal positioning of the devices to increase chances of thrombus formation. Eight devices were positioned non-optimally. Three devices were positioned in the main PA instead of the left and right PA. Pre-interventional PA geometries were reconstructed from the respective CT images, and the devices were virtually implanted at the exact sites and orientations indicated by the follow-up CT after one month. Transient intra-arterial hemodynamics were calculated using computational fluid dynamics. Volume flow rates were modelled specifically matching the animals body weights. Wall shear stresses (WSS) and oscillatory shear indices (OSI) before and after device implantation were compared. Simulations revealed no relevant changes in any investigated hemodynamic parameters due to device implantation. Even in cases, where devices were implanted in a non-optimal manner, no marked differences in hemodynamic parameters compared to devices implanted in an optimal position were found. Before implantation time and surface-averaged WSS was 2.35±0.47 Pa, whereas OSI was 0.08±0.17, respectively. Areas affected by low WSS magnitudes were 2.5±2.7 cm2, whereas the areas affected by high OSI were 18.1±6.3 cm2. After device implantation, WSS and OSI were 2.45±0.49 Pa and 0.08±0.16, respectively. Surface areas affected by low WSS and high OSI were 2.9±2.7 cm2, and 18.4±6.1 cm2, respectively. This in-silico study indicates that no clinically relevant differences in intra-arterial hemodynamics are occurring after device implantation, even at non-optimal positioning of the sensor. Simultaneously, no embolic events were observed, suggesting that the risk for thrombus formation after device implantation is low and independent of the sensor position.

【 授权许可】

Unknown   
© 2023 Brüning, Yevtushenko, Schlief, Jochum, van Gijzen, Meine, Romberg, Kuehne, Arndt and Goubergrits.