Polysaccharides: potential bioactive macromolecules for Alzheimer’s disease

Frontiers in Nutrition

Nutrition

Ming Li¹  Zhaoli Meng²  Gong Peng² 

[1] Department of Neurology, The Second Hospital of Nanchang University, Nanchang, China;Laboratory of Tumor Immunology, The First Hospital of Jilin University, Changchun, China;

关键词: polysaccharide;    Alzheimer’s disease;    amyloid-beta;    oxidative stress;    inflammation;   

DOI  :  10.3389/fnut.2023.1249018

 received in 2023-06-28, accepted in 2023-09-01,  发布年份 2023

来源: Frontiers

【 摘 要 】

Alzheimer’s disease (AD) is one of the leading causes of death and disability. AD is a devastating disease that has caused an overwhelming burden. However, no disease-modified treatment was discovered. The approval of sodium oligomannate (GV-971) in mild-moderate AD patients has attracted great attention to investigate the role of saccharides in AD. Therefore, summarizing and explaining the role of saccharides in AD is urgent and promising. Recent studies showed that polysaccharides (PSs) potentially benefit AD in vitro and in vivo. PSs could alleviate the pathological damage and improve cognitive symptoms via (1) antagonizing the toxicity of abnormal amyloid-beta and tau proteins; (2) attenuating oxidative stress and proinflammation; (3) rebuilding neuroplasticity. PSs exhibit one-multiple pathological hits of AD. However, a thorough chemical investigation is needed for further study.

【 授权许可】

Unknown   
Copyright © 2023 Peng, Li and Meng.