Recent advances in the repair of degenerative intervertebral disc for preclinical applications

Frontiers in Bioengineering and Biotechnology

Bioengineering and Biotechnology

Kaiwen Cai¹  Kefeng Luo¹  Guoqiang Jiang¹  Kai Zhang¹  Rongzhang Qiu²  Yijian Ying²  Xiongxiong Cai² 

[1] Department of Orthopaedics, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang, China;Health Science Center, Ningbo University, Ningbo, Zhejiang, China;

关键词: intervertebral disc;    fibrous annulus;    degeneration;    repair;    tissue engineering;    biomaterials;    hydrogel;    scaffold;   

DOI  :  10.3389/fbioe.2023.1259731

 received in 2023-07-16, accepted in 2023-09-14,  发布年份 2023

来源: Frontiers

【 摘 要 】

The intervertebral disc (IVD) is a load-bearing, avascular tissue that cushions pressure and increases flexibility in the spine. Under the influence of obesity, injury, and reduced nutrient supply, it develops pathological changes such as fibular annulus (AF) injury, disc herniation, and inflammation, eventually leading to intervertebral disc degeneration (IDD). Lower back pain (LBP) caused by IDD is a severe chronic disorder that severely affects patients’ quality of life and has a substantial socioeconomic impact. Patients may consider surgical treatment after conservative treatment has failed. However, the broken AF cannot be repaired after surgery, and the incidence of re-protrusion and reoccurring pain is high, possibly leading to a degeneration of the adjacent vertebrae. Therefore, effective treatment strategies must be explored to repair and prevent IDD. This paper systematically reviews recent advances in repairing IVD, describes its advantages and shortcomings, and explores the future direction of repair technology.

【 授权许可】

Unknown   
Copyright © 2023 Ying, Cai, Cai, Zhang, Qiu, Jiang and Luo.