IGF Signaling in Intervertebral Disc Health and Disease

Frontiers in Cell and Developmental Biology

卷:9

Hui Lin¹  Ling Wu¹  Shuo Tian¹  Xiangcheng Qing¹  Zengwu Shao¹  Yizhong Peng¹  Yan Xiao² 

[1] Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;

[2] Department of Radiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China;

关键词: insulin-like growth factor;    intervertebral disc;    nucleus pulposus;    degeneration;    low back pain;   

DOI  :  10.3389/fcell.2021.817099

来源: DOAJ

【 摘 要 】

Low back pain (LBP) is a common musculoskeletal symptom, which brings a lot of pain and economic loss to patients. One of the most common causes of LBP is intervertebral disc degeneration (IVDD). However, pathogenesis is still debated, and therapeutic options are limited. Insulin-like growth factor (IGF) signaling pathways play an important role in regulating different cell processes, including proliferation, differentiation, migration, or cell death, which are critical to the homeostasis of tissues and organs. The IGF signaling is crucial in the occurrence and progression of IVDD. The activation of IGF signaling retards IVDD by increasing cell proliferation, promoting extracellular matrix (ECM) synthesis, inhibiting ECM decomposition, and preventing apoptosis and senescence of disc cells. However, abnormal activation of IGF signaling may promote the process of IVDD. IGF signaling is currently considered to have a promising treatment prospect for IVDD. An in-depth understanding of the role of IGF signaling in IVDD may help find a novel approach for IVDD treatment.

【 授权许可】

Unknown