Investigations into the effects of scaffold microstructure on slow-release system with bioactive factors for bone repair

Frontiers in Bioengineering and Biotechnology

Bioengineering and Biotechnology

Baoqing Pei¹  Shijia Zhang¹  Le Zhang¹  Mengyuan Hu¹  Xueqing Wu¹  Da Lu¹  Shuqin Wu² 

[1] Beijing Key Laboratory for Design and Evaluation Technology of Advanced Implantable and Interventional Medical Devices, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China;School of Big Data and Information, Shanxi College of Technology, Taiyuan, Shanxi, China;

关键词: bone tissue engineering;    bioactive factor;    slow-release system;    scaffold microstructure;    bone repair;   

DOI  :  10.3389/fbioe.2023.1230682

 received in 2023-05-29, accepted in 2023-09-01,  发布年份 2023

来源: Frontiers

【 摘 要 】

In recent years, bone tissue engineering (BTE) has played an essential role in the repair of bone tissue defects. Although bioactive factors as one component of BTE have great potential to effectively promote cell differentiation and bone regeneration, they are usually not used alone due to their short effective half-lives, high concentrations, etc. The release rate of bioactive factors could be controlled by loading them into scaffolds, and the scaffold microstructure has been shown to significantly influence release rates of bioactive factors. Therefore, this review attempted to investigate how the scaffold microstructure affected the release rate of bioactive factors, in which the variables included pore size, pore shape and porosity. The loading nature and the releasing mechanism of bioactive factors were also summarized. The main conclusions were achieved as follows: i) The pore shapes in the scaffold may have had no apparent effect on the release of bioactive factors but significantly affected mechanical properties of the scaffolds; ii) The pore size of about 400 μm in the scaffold may be more conducive to controlling the release of bioactive factors to promote bone formation; iii) The porosity of scaffolds may be positively correlated with the release rate, and the porosity of 70%–80% may be better to control the release rate. This review indicates that a slow-release system with proper scaffold microstructure control could be a tremendous inspiration for developing new treatment strategies for bone disease. It is anticipated to eventually be developed into clinical applications to tackle treatment-related issues effectively.

【 授权许可】

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Copyright © 2023 Pei, Hu, Wu, Lu, Zhang, Zhang and Wu.