Changes in smoking, alcohol consumption, and the risk of Parkinson’s disease

Frontiers in Aging Neuroscience

Aging Neuroscience

Juhwan Yoo¹  Jung Eun Yoo²  Se Young Jung³  Yohwan Yeo⁴  Su Min Jeong⁴  Dong Wook Shin⁵  Eun Bin Cho⁶  Ju-Hong Min⁷  Kyungdo Han⁸  Sohyun Chun⁹ 

[1] Department of Biostatistics, The Catholic University of Korea, Seoul, Republic of Korea;Department of Family Medicine, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, Republic of Korea;Department of Family Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea;Department of Digital Healthcare, Seoul National University Bundang Hospital, Seongnam, Republic of Korea;Department of Family Medicine/Supportive Care Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea;Department of Family Medicine/Supportive Care Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea;Department of Clinical Study Design and Evaluation, Samsung Advanced Institute of Health Science and Technology (SAIHST), Sungkyunkwan University, Seoul, Republic of Korea;Center for Wireless and Population Health Systems, University of California, San Diego, La Jolla, CA, United States;Department of Neurology, College of Medicine, Gyeongsang Institute of Health Science, Gyeongsang National University, Jinju, Republic of Korea;Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea;Neuroscience Center, Samsung Medical Center, Seoul, Republic of Korea;Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences and Technology (SAIHST), Sungkyunkwan University, Seoul, Republic of Korea;Department of Statistics and Actuarial Science, Soongsil University, Seoul, Republic of Korea;International Healthcare Center, Samsung Medical Center, Seoul, Republic of Korea;

关键词: cigarette smoking;    alcohol consumption;    Parkinson’s disease;    Asia;    nicotine;   

DOI  :  10.3389/fnagi.2023.1223310

 received in 2023-05-16, accepted in 2023-08-21,  发布年份 2023

来源: Frontiers

【 摘 要 】

ObjectiveThere have been no studies on the association between changes in smoking and alcohol consumption or combined changes in smoking and alcohol consumption frequencies and PD risk. To assess the influence of changes in smoking and alcohol consumption on the risk of Parkinson’s disease (PD).MethodsNational Health Insurance Service (NHIS) database between January 2009 to December 2011 was analyzed. A total of 3,931,741 patients were included. Study participants were followed up for the incidence of PD until December 2017.ResultsCompared to the sustained non-smokers, sustained light smokers (adjusted hazard ratio [aHR] 0.80, 95% confidence interval [CI] 0.75–0.85), sustained moderate smokers (aHR 0.54, 95% CI 0.47–0.61), and sustained heavy smokers (aHR 0.49, 95% CI 0.44–0.55) had a lower risk of PD. Compared to those who sustained non-drinking, sustained light drinkers (aHR 0.85 95% CI 0.89–0.91), sustained moderate drinkers (aHR 0.68, 95% CI 0.60–0.78), and sustained heavy drinkers (aHR 0.77, 95% CI 0.68–0.87) showed decreased risk of PD. Among non-drinkers, those who started drinking to a light level were at decreased risk of PD (aHR 0.84, 95% CI 0.77–0.91). Among non-smoking and non-drinking participants, those who initiated smoking only (aHR 0.78, 95% CI 0.70–0.86), drinking only (aHR 0.77, 95% CI 0.68–0.87), and both smoking and drinking (aHR 0.69, 95% CI 0.58–0.82) showed decreased risk of PD.ConclusionSmoking is associated with decreased risk of PD with a dose–response relationship. Alcohol consumption at a light level may also be associated with decreased risk of PD. Further studies are warranted to find the possible mechanisms for the protective effects of smoking and drinking on PD, which may present insights into the etiology of PD.

【 授权许可】

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Copyright © 2023 Jung, Chun, Cho, Han, Yoo, Yeo, Yoo, Jeong, Min and Shin.