Risk of Spina Bifida and Maternal Cigarette, Alcohol, and Coffee Use during the First Month of Pregnancy

International Journal of Environmental Research and Public Health

Corey M. Benedum¹  Mahsa M. Yazdy¹  Allen A. Mitchell¹ 

[1] Slone Epidemiology Center at Boston University, 1010 Commonwealth Ave. Boston, MA 02215, USA;

关键词: spina bifida;    alcohol consumption;    caffeine consumption;    cigarettes;    folic acid;    birth defects;   

DOI  :  10.3390/ijerph10083263

来源: mdpi

【 摘 要 】

This study was conducted to assess the association between the risks of spina bifida (SB) in relation to cigarette, alcohol, and caffeine consumption by women during the first month of pregnancy. Between 1988–2012, this multi-center case-control study interviewed mothers of 776 SB cases and 8,756 controls about pregnancy events and exposures. We evaluated cigarette smoking, frequency of alcohol drinking, and caffeine intake during the first lunar month of pregnancy in relation to SB risk. Logistic regression models were used to calculate adjusted odds ratios and 95% confidence intervals. Levels of cigarette smoking (1–9 and ≥10/day), alcohol intake (average ≥4 drinks/day) and caffeine intake (<1, 1, and ≥2 cups/day) were not likely to be associated with increased risk of SB. Further, results were similar among women who ingested less than the recommended amount of folic acid (400 μg/day).

【 授权许可】

CC BY   
© 2013 by the authors; licensee MDPI, Basel, Switzerland.