ToxRefDB v2.1: update to curated in vivo study data in the Toxicity Reference Database

Frontiers in Toxicology

Toxicology

Madison Feshuk¹  Katie Paul Friedman¹  Sean Watford²  Lori Kolaczkowski³ 

[1] Center for Computational Toxicology and Exposure, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, Washington, DC, United States;Center for Public Health and Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, Washington, DC, United States;National Student Services Contractor, Oak Ridge Associated Universities, Oak Ridge, TN, United States;

关键词: database;    toxicity;    in vivo;    reference;    NAMs;    curation;   

DOI  :  10.3389/ftox.2023.1260305

 received in 2023-07-17, accepted in 2023-08-21,  发布年份 2023

来源: Frontiers

【 摘 要 】

The Toxicity Reference Database (ToxRefDB) contains in vivo study data from over 5,900 guideline or guideline-like studies for over 1,100 chemicals. The database includes information regarding study design, chemical treatment, dosing, treatment group parameters, treatment-related (significantly different from control) and critical (adverse) effects, guided by a controlled effect vocabulary, as well as endpoint testing status according to health effects guideline requirements. ToxRefDB v2.1 is an update to address a compilation error found in ToxRefDB v2.0 that resulted in some effects being inadvertently omitted from the database. Though effect data has been recovered, no new studies were added. The recovered data improves the utility of ToxRefDB as a resource for curated legacy in vivo information, which enhances scientific confidence in vitro high-throughput screening of chemicals and supports retrospective and predictive toxicology applications for which outcomes in traditional regulatory toxicology studies serve as reference information.

【 授权许可】

Unknown   
Copyright © 2023 Feshuk, Kolaczkowski, Watford and Paul Friedman.