Mean arterial pressure trajectory with premature cardiovascular disease and all-cause mortality in young adults: the Kailuan prospective cohort study

Frontiers in Cardiovascular Medicine

Cardiovascular Medicine

Shouling Wu¹  Haiyan Zhao¹  Shuohua Chen¹  YunTao Wu¹  Peng Yang²  Zhihao Wei³  Yun Li³  Zongshuang Song³  Yizhen Tan³  Wenliu Zhao³ 

[1] Department of Cardiology, Kailuan General Hospital, Tangshan, China;Department of Neurosurgery, Affiliated Hospital of North China University of Science and Technology, Tangshan, China;School of Public Health, North China University of Science and Technology, Tangshan, China;

关键词: blood pressure pattern;    trajectory;    cardiovascular diseases;    all-cause mortality;    young people;   

DOI  :  10.3389/fcvm.2023.1222995

 received in 2023-05-15, accepted in 2023-09-04,  发布年份 2023

来源: Frontiers

【 摘 要 】

BackgroundThe association between mean arterial pressure (MAP) trajectory in young adults and risk of cardiovascular diseases (CVD) and all-cause mortality is not well-characterized. The objective of this study was to investigate the effects of different MAP trajectory on the risk of CVD and all-cause mortality among the young.MethodsIn the Kailuan cohort study, 19,171 participants aged 18–40 years were enrolled without CVD (including myocardial infarction, stroke, atrial fibrillation and heart failure). The potential hybrid model was used to fit different trajectory patterns according to longitudinal changes of MAP. Hazard ratios and 95% confidence intervals for risk of CVD and all-cause mortality were analyzed using Cox proportional hazard regression models for participants with different trajectories.ResultsFive distinct MAP trajectories were identified during 2006–2013. Each of the trajectories was labelled as low-stable, middle-stable, decreasing, increasing, or high-stable. With the low-stable trajectory group as the reference, the multivariate adjusted HR (95%CI) of CVD for the middle-stable, decreasing, increasing and high-stable groups were 2.49 (1.41–4.40), 5.18 (2.66–10.06), 5.91 (2.96–11.80) and 12.68 (6.30–25.51), respectively. The HR (95%CI) for all-cause deaths were 1.27 (0.84–1.94), 2.01 (1.14–3.55), 1.96 (1.04–4.3.72), and 3.28 (1.69–6.37), respectively.ConclusionIn young adults, MAP trajectories were associated with the risk of CVD or all-cause mortality and increasing MAP trajectories within the currently designated “normal” range may still increase the risk for CVD.

【 授权许可】

Unknown   
© 2023 Song, Zhao, Wei, Zhao, Tan, Yang, Chen, Wu, Li and Wu.