Association between android fat mass, gynoid fat mass and cardiovascular and all-cause mortality in adults: NHANES 2003–2007

Frontiers in Cardiovascular Medicine

Cardiovascular Medicine

Haytham A. Sheerah¹  Xiaobing Zhai²  Kokoro Shirai³  Keyang Liu³  Jinhong Cao⁴  Xinyi Yu⁵  Huiping Zhu⁵  Wenzhi Ma⁶  Nian Huang⁶  Shiyang Li⁶ 

[1] Assistant Deputyship for International Collaborations, Ministry of Health, Riyadh, Saudi Arabia;Center for Artificial Intelligence Driven Drug Discovery, Faculty of Applied Sciences, Macao Polytechnic University, Macao, China;Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Suita-shi, Japan;School of Management, Hubei University of Chinese Medicine, Wuhan, China;Research Center for the Development of Chinese Medicine, Hubei Province Project of Key Research Institute of Humanities and Social Sciences at Universities, Wuhan, China;School of Public Health, Capital Medical University, Beijing, China;School of Public Health, Wuhan University, Wuhan, China;

关键词: android fat mass;    gynoid fat mass;    cardiovascular diseases;    all-cause mortality;    NHANES;   

DOI  :  10.3389/fcvm.2023.1055223

 received in 2022-09-27, accepted in 2023-04-14,  发布年份 2023

来源: Frontiers

【 摘 要 】

ObjectivesEvidence of the relationship between android fat mass and gynoid fat mass with the mortality prediction is still limited. Current study analyzed the NHANES database to investigate the relationship between android fat mass, gynoid fat mass and CVD, with all-cause mortality.MethodThe study subjects were NHANES participants over 20 years old, two indicators of regional body composition, android fat and gynoid fat were measured by Dual Energy x-ray Absorptiometry (DEXA). The other various covariates data obtained from the NHANES questionnaire and laboratory measurements, including age, gender, education, race/ethnicity, uric acid, total serum cholesterol, albumin, Vitamin C, folate, alcohol drinking, smoking status, history of diabetes, and hypertension. Mortality status was ascertained from a linked mortality file prepared by the National Center for Health Statistics. The study population was divided quartiles based on the distribution of android fat mass and gynoid fat mass. The relationship between these two indicators with cardiovascular and all-cause mortality was investigated by using Cox regression. The covariates age, gender, smoking status, drinking status, history of diabetes, and history of hypertension were stratified.ResultsIn the fully adjusted model, Q3 had the lowest HR in android fat mass and gynoid fat mass. When examining the relationship between android fat mass and CVD mortality, current smokers and drinkers had the lowest CVD risk in Q2 [smoking: 0.21 (0.08, 0.52), drinking: 0.14 (0.04, 0.50)]. In diabetic patients, compared with Q1, other groups with increased android fat mass can significantly reduce the risk of CVD [Q4: 0.17 (0.04, 0.75), Q3: 0.18 (0.03, 1.09), Q2: 0.27 (0.09, 0.83)]. In ≥60 years old and female, the greater the gynoid fat mass, the smaller the HR of all-cause mortality [Q4 for ≥60 years old: 0.57 (0.33, 0.96), Q4 for female: 0.37 (0.23, 0.58)]. People <60 years old had a lower risk of all-cause mortality with gynoid fat mass in Q3 than those ≥60 years old [<60 years: 0.50 (0.27, 0.91), ≥60 years: 0.65 (0.45, 0.95)]. Among subjects without hypertension, the group with the largest android fat mass had the lowest risk of CVD mortality, and the group with the largest gynoid fat mass had the lowest risk of all-cause mortality [Android fat mass: 0.36 (0.16, 0.81), gynoid fat mass: 0.57 (0.39, 0.85)].ConclusionModerate android fat mass and gynoid fat mass (Q3) had the most protective effect. Smokers and drinkers need to control their body fat. Being too thin is harmful to people with diabetes. Increased gynoid fat mass is a protective factor for all-cause mortality in older adults and females. Young people's gynoid fat mass is more protective in the moderate range than older people's. If no high blood pressure exists, people with more android and gynoid fat mass have a lower risk of CVD or all-cause mortality.

【 授权许可】

Unknown   
© 2023 Ma, Zhu, Yu, Zhai, Li, Huang, Liu, Shirai, Sheerah and Cao.