The role of DC-SIGN as a trans-receptor in infection by MERS-CoV

Frontiers in Cellular and Infection Microbiology

Cellular and Infection Microbiology

Nuria Labiod¹  Joanna Luczkowiak¹  María M. Tapia¹  Fátima Lasala¹  Rafael Delgado² 

[1] Department of Microbiology, Instituto de Investigación Hospital Universitario 12 de Octubre (Imas12), Madrid, Spain;Department of Microbiology, Instituto de Investigación Hospital Universitario 12 de Octubre (Imas12), Madrid, Spain;Departamento de Medicina, Facultad de Medicina, Universidad Complutense, Madrid, Spain;CIBERINFEC, Instituto de Salud Carlos III, Madrid, Spain;

关键词: MERS-CoV;    Coronaviruses;    DC-SIGN;    receptors;    dendritic cell;   

DOI  :  10.3389/fcimb.2023.1177270

 received in 2023-03-01, accepted in 2023-08-28,  发布年份 2023

来源: Frontiers

【 摘 要 】

DC-SIGN is a C-type lectin expressed in myeloid cells such as immature dendritic cells and macrophages. Through glycan recognition in viral envelope glycoproteins, DC-SIGN has been shown to act as a receptor for a number of viral agents such as HIV, Ebola virus, SARS-CoV, and SARS-CoV-2. Using a system of Vesicular Stomatitis Virus pseudotyped with MERS-CoV spike protein, here, we show that DC-SIGN is partially responsible for MERS-CoV infection of dendritic cells and that DC-SIGN efficiently mediates trans-infection of MERS-CoV from dendritic cells to susceptible cells, indicating a potential role of DC-SIGN in MERS-CoV dissemination and pathogenesis.

【 授权许可】

Unknown   
Copyright © 2023 Labiod, Luczkowiak, Tapia, Lasala and Delgado