Mesenchymal stromal/stem cells and their extracellular vesicles in liver diseases: insights on their immunomodulatory roles and clinical applications

Cell & Bioscience

Review

Qian Huai¹  Xiaolei Li¹  Hanren Dai¹  Xu Zhang¹  Cheng Zhu¹  Hua Wang² 

[1] Department of Oncology, The First Affiliated Hospital of Anhui Medical University, 230022, Hefei, China;Department of Oncology, The First Affiliated Hospital of Anhui Medical University, 230022, Hefei, China;Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Medical University, 230032, Hefei, China;

关键词: Mesenchymal stromal cell;    Extracellular vesicles;    Liver disease;    Immunomodulation;    Clinical application;   

DOI  :  10.1186/s13578-023-01122-3

 received in 2023-05-24, accepted in 2023-08-30,  发布年份 2023

来源: Springer

【 摘 要 】

Liver disease is a leading cause of mortality and morbidity that is rising globally. Liver dysfunctions are classified into acute and chronic diseases. Various insults, including viral infections, alcohol or drug abuse, and metabolic overload, may cause chronic inflammation and fibrosis, leading to irreversible liver dysfunction. Up to now, liver transplantation could be the last resort for patients with end-stage liver disease. However, liver transplantation still faces unavoidable difficulties. Mesenchymal stromal/stem cells (MSCs) with their broad ranging anti-inflammatory and immunomodulatory properties can be effectively used for treating liver diseases but without the limitation that are associated with liver transplantation. In this review, we summarize and discuss recent advances in the characteristics of MSCs and the potential action mechanisms of MSCs-based cell therapies for liver diseases. We also draw attention to strategies to potentiate the therapeutic properties of MSCs through pre-treatments or gene modifications. Finally, we discuss progress toward clinical application of MSCs or their extracellular vesicles in liver diseases.

【 授权许可】

CC BY   
© Society of Chinese Bioscientists in America (SCBA) 2023

【 图 表 】

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