Disruption of EEG resting state functional connectivity in patients with focal epilepsy

The Egyptian Journal of Neurology, Psychiatry and Neurosurgery

Research

Mostafa M. Elkholy¹ 

[1] Department of Clinical Neurophysiology (Neuro-Diagnostic and Research Center), Faculty of Medicine, Beni-Suef University, Hadayek AlAhram-Gate(3)-132(S), 12522, Giza, Egypt;

关键词: Functional connectivity;    Electroencephalography;    Coherence;    Phase lag;    Focal epilepsy;    Epileptic networks;   

DOI  :  10.1186/s41983-023-00727-2

 received in 2023-05-26, accepted in 2023-08-19,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundEpilepsy is a network disease and EEG could be used to evaluate dynamic inter-regional connectivity. The aim of the current study is to explore disruption of resting state EEG functional connectivity in focal epilepsy using coherence and phase lag degree. This cross-sectional study included 30 patients with focal epilepsy and 30 matched healthy controls. One to two minutes of EEG segmented into 2-s epochs during awake eye-closed state were analyzed using fast Fourier transform to yield four frequency bands: delta, theta, alpha and beta. Coherence and phase lag degree were computed between each pair of 19 EEG electrodes and were assessed at the intra-hemispheric (frontal–parietal and frontal–temporal) and inter-hemispheric (frontal, temporal and parietal) levels. The frequency of interictal epileptiform discharges (IEDs) was calculated from a 60-min EEG recording session.ResultsCompared to healthy controls, patients had lower theta coherence at left frontal–parietal (P = 0.017), lower delta coherence at inter-frontal (P = 0.045), higher theta phase lag at right frontal–parietal (P = 0.01) and lower delta phase lag at inter-temporal (P = 0.046) levels. Patients with left-sided epilepsy had lower theta coherence at left frontal–parietal (P = 0.026), higher theta phase lag at right frontal–parietal (P < 0.001), higher delta phase lag at right frontal–temporal (P = 0.036) and higher theta phase lag at inter-parietal (P = 0.028) levels. The frequency of IEDs correlated with phase lag of delta (P = 0.036, r = 0.406) and theta (P = 0.005, r = 0.513).ConclusionsPatients with focal epilepsy had significant interictal functional connectivity disruption detected by coherence and phase lag degree of delta and theta waves and correlated with frequency of IEDs.

【 授权许可】

CC BY   
© Egyptian Society of Neurology, Psychiatry, and Neurosurgery 2023

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