A highly sensitive and green electroanalytical method for the determination of favipiravir in pharmaceutical and biological fluids

BMC Chemistry

Research

Heba M. El-Sayed¹  Hisham Ezzat Abdellatef¹  Hassan A. M. Hendawy²  Hany Ibrahim³  Omar M El-Abassy³ 

[1] Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, 44519, Zagazig, Egypt;Egyptian Drug Authority, Giza, Egypt;Pharmaceutical Chemistry Department, Faculty of Pharmacy, Egyptian Russian University, 11829, Badr, Egypt;

关键词: Favipiravir;    Reduced graphene oxide;    Square wave voltammetry;    Cyclic voltammetry;   

DOI  :  10.1186/s13065-023-01023-z

 received in 2022-09-25, accepted in 2023-08-17,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundFavipiravir is currently used for the treatment of coronavirus disease-2019 (COVID-19).ObjectiveA highly sensitive and eco-friendly electroanalytical method was developed to quantify favipiravir.MethodThe voltammetric method optimized a sensor composed of reduced graphene oxide / modified carbon paste electrode in the presence of an anionic surfactant, improving the favipiravir detection limit. The investigation reveals that favipiravir-oxidation is a diffusion-controlled irreversible process. The effects of various pH and scan rates on oxidation anodic peak current were investigated.ResultsThe developed method offers a wide linear dynamic range of 1.5–420 ng/mL alongside a higher sensitivity with a limit of detection in the nanogram range (0.44 ng/mL) and a limit of quantification in the low nanogram range (1.34 ng/mL).ConclusionThe proposed method was applied for the determination of favipiravir in the dosage form, human plasma and urine samples. The developed method exhibited good selectivity in the presence of two potential electroactive biological interferants, uric acid which increases during favipiravir therapy and the recommended co-administered vitamin C. The organic solvent-free method greenness was evaluated via the Green Analytical Procedure Index, The present work offers a simple, sensitive and environment-friendly method fulfilling green chemistry concepts.

【 授权许可】

CC BY   
© Springer Nature Switzerland AG 2023

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