Knowledge, attitude and perceptions of pharmacists regarding renal dose adjustment among chronic kidney disease patients in Pakistan

Journal of Pharmaceutical Policy and Practice

Research

Yasar Shah¹  Inayat Ur Rehman¹  Roheena Zafar²  Zahid Ali³  Tahir Mehmood Khan⁴  Long Chiau Ming⁵ 

[1] Department of Pharmacy, Abdul Wali Khan University Mardan, 23200, Mardan, Pakistan;Department of Pharmacy, Abdul Wali Khan University Mardan, 23200, Mardan, Pakistan;Department of Pharmacy, Northwest General Hospital and Research Centre, 25100, Peshawar, Pakistan;Department of Pharmacy, University of Peshawar, 25120, Peshawar, Pakistan;Institute of Pharmaceutical Sciences, University of Veterinary and Animal Sciences, 54000, Lahore, Pakistan;School of Medical and Life Sciences, Sunway University, 47500, Bandar Sunway, Malaysia;

关键词: Knowledge;    Attitude;    Perception;    Renal dose adjustment;    RDQ-13;    Pakistan;   

DOI  :  10.1186/s40545-023-00606-4

 received in 2023-07-06, accepted in 2023-09-13,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundChronic kidney disease (CKD) poses a significant public health challenge. CKD patients have compromised renal function, which not only alters the pharmacokinetics of drugs but also their pharmacodynamics. Adjusting drug doses for these patients is essential to achieve the intended clinical outcomes, prevent adverse drug events, and halt further progression of the disease. Pharmacists play a pivotal role in ensuring safe and appropriate therapy for CKD patients. However, there is a noticeable absence of national dosing guidelines for CKD in Pakistan, coupled with a scarcity of studies exploring the knowledge, attitude, and perception of renal dose adjustments in the country. This study aimed to evaluate the knowledge, attitudes, and perceptions of pharmacists in the Khyber Pakhtunkhwa province and Islamabad regarding renal dose adjustments.MethodologyA cross-sectional study was conducted to gauge the knowledge, attitude, and perception of pharmacists working in various cities of Khyber Pakhtunkhwa and the capital city, Islamabad, from February to May 2023. The Renal Dosing Questionnaire-13 (RDQ-13) scale was employed for this purpose. The survey link was disseminated through emails, and the RDQ-13 scale was also completed in person by pharmacists from hospitals, clinics, community, and retail settings who interact with CKD patients. Univariate linear regression was employed, and factors with a p value < 0.25 were subjected to multivariate linear regression. For comparing knowledge, attitude, and perception scores of pharmacists, the independent t test and one-way ANOVA were utilized as appropriate. A p value < 0.05 was deemed statistically significant.ResultsOf the 384 pharmacists approached, 270 completed the RDQ-13 scale, resulting in a response rate of 70.3%. The overall knowledge score regarding renal dose adjustment was 21.24 ± 2.18 (mean ± SD). Attitude scores averaged at 10.04 ± 1.81, and perception scores at 7.19 ± 2.15. Multivariate analysis indicated a positive correlation between the pharmacists' perception scores and gender, with male pharmacists scoring higher than their female counterparts.ConclusionsThe study underscores the importance of instituting targeted training programs for pharmacists, ensuring access to dependable resources, and promoting research and results dissemination in the realm of renal pharmacotherapy to enhance public health outcomes.

【 授权许可】

CC BY   
© Dr. Zaheer-Ud-Din Babar and Auckland UniServices Ltd. 2023

【 图 表 】

Fig. 12