Antidepressants and type 2 diabetes: highways to knowns and unknowns

Diabetology & Metabolic Syndrome

Review

Ali I. Al-Gareeb¹  Ali K. Albuhadily¹  Hayder M. Al-Kuraishy¹  Amany E. Ragab²  Gaber El-Saber Batiha³  Athanasios Alexiou⁴  Marios Papadakis⁵  Nahi Sabih Alruwaili⁶  Ahmad Awad Alenazi⁷ 

[1] Department of Clinical pharmacology and Medicine, College of Medicine, Mustansiriyah University, Baghdad, Iraq;Department of Pharmacognosy, Faculty of Pharmacy, Tanta University, Tanta, Egypt;Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, 22511, Damanhour, AlBeheira, Egypt;Department of Science and Engineering, Novel Global Community Educational Foundation, 2770, Hebersham, NSW, Australia;AFNP Med, 1030, Wien, Austria;Department of Surgery II, University Hospital Witten-Herdecke, 42283, Wuppertal, Germany;Eradah Complex of Mental Health -Northern Border Region, Ministry of Health, Al Bahah, Saudi Arabia;National guard health affairs, Riyadh, Saudi Arabia;

关键词: Type 2 diabetes;    Depression;    Antidepressants;   

DOI  :  10.1186/s13098-023-01149-z

 received in 2023-04-26, accepted in 2023-08-09,  发布年份 2023

来源: Springer

【 摘 要 】

Type 2 diabetes (T2D) is a metabolic disease caused by the development of insulin resistance (IR), relative insulin deficiency, and hyperglycemia. Hyperglycemia-induced neurochemical dysregulation activates the progression of depression in T2D patients. Therefore, management of depression by antidepressant agents improves glucose homeostasis and insulin sensitivity. However, prolong use of antidepressant drugs may increase the risk for the development of T2D. However, there is strong controversy concerning the use of antidepressant drugs in T2D. Therefore, this review try to elucidate the potential effects of antidepressant drugs in T2D regarding their detrimental and beneficial effects.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

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