Depression and glycemic intake in the homebound elderly

JOURNAL OF AFFECTIVE DISORDERS

卷:132

Article

Mwamburi, D. Mkaya³  Liebson, Elizabeth⁴  Folstein, Marshal⁵  Bungay, Kathleen⁶  Tucker, Katherine L.⁷  Qiu, Wei Qiao^1,2 

[1] Boston Univ, Sch Med, Dept Pharmacol & Psychiat, Boston, MA 02118 USA

[2] Boston Univ, Sch Med, Dept Expt Therapeut, Boston, MA 02118 USA

[3] Tufts Univ, Dept Publ Hlth & Family Med, Medford, MA 02155 USA

[4] Harvard Univ, Sch Med, McLean Hosp, Cambridge, MA 02138 USA

[5] Tufts Univ, Gerald J & Dorothy R Friedman Sch Nutr Sci & Poli, Medford, MA 02155 USA

[6] Northeastern Univ, Dept Pharm Practice, Boston, MA USA

[7] Northeastern Univ, Dept Hlth Sci, Boston, MA USA

关键词: Depression;    Glycemic intake;    Antidepressants;    Type 2 diabetes;    Elderly;   

DOI  :  10.1016/j.jad.2011.02.002

来源: Elsevier

【 摘 要 】

Background: Depression is associated with an increase in the incidence of type 2 diabetes, but the mechanism is unclear. We aimed to study the relationship between depression and glycemic intake in the elderly, and examine whether antidepressant use modified this relationship. Design, setting and participants: We evaluated 976 homebound elders in a cross-sectional study. Depression was defined by having a Center for Epidemiological Studies Depression (CES-D) score >= 16. Antidepressant use was documented. Glycemic index (GI), Glycemic load (GL), and fasting blood insulin levels were measured. Results: Depressed elders had slightly higher GI (Mean +/- SD: 55.8 +/- 3.8 vs. 55.1 +/- 3.7, P=0.003) and higher insulin levels (Median: 84.0 vs. 74.4 pmol/ml, P=0.05) than non-depressed elders. Depressed elders receiving antidepressants, primarily selective serotonin reuptake inhibitors (SSRI), had lower Cl (Mean +/- SD: 55.1 +/- 4.7 vs. 56.2 +/- 3.4, P=0.002) and GL (Median: 1703 vs. 6826.3, P=0.03) than those not taking antidepressants. After adjusting for potential confounding variables, GI remained positively associated with depression (beta= + 0.65, SE = 0.28, P = 0.02); the logarithm of GL was positively associated with depression (beta= +0.33, SE = 0.17, P = 0.05) and negatively associated with antidepressant use (beta = -0.54, SE = 0.18, P = 0.003). Conclusions: Prospective studies are needed to examine whether high glycemic intake is a mediating factor between late life depression and the risk of type 2 diabetes. (C) 2011 Elsevier B.V. All rights reserved.

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