Genotype variation of ACE and ACE2 genes affects the severity of COVID-19 patients

BMC Research Notes

Research Note

Eko Supriyanto¹  Nadia F. Syafhan²  Amarila Malik³  Deli Marteka⁴  Ingrid Faustine⁵ 

[1]Department of Biomedical Engineering & Health Science, Universiti Teknologi Malaysia, Johor Bahru, 81310, Johor, Malaysia

[2]Division of Clinical Pharmacy, Faculty of Pharmacy, Universitas Indonesia, 16424, Depok, West Java, Indonesia

[3]Universitas Indonesia Hospital, Jl. Prof. Dr. Bahder Djohan, Pondok Cina, 16424, Depok, West Java, Indonesia

[4]Division of Pharmaceutical Microbiology and Biotechnology, Faculty of Pharmacy, Universitas Indonesia, 16424, Depok, West Java, Indonesia

[5]Faculty of Pharmacy, Universitas Indonesia, 16424, Depok, West Java, Indonesia

[6]Faculty of Pharmacy, Universitas Indonesia, 16424, Depok, West Java, Indonesia

[7]Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Tadulako University, 94148, Palu, Central Sulawesi, Indonesia

关键词: ACE;    ACE2;    rs4331;    rs2074192;    COVID-19;    Indonesian population;    Hypertension comorbide;    rhAmp SNP genotyping;   

DOI  :  10.1186/s13104-023-06483-z

 received in 2023-05-26, accepted in 2023-08-29,  发布年份 2023

来源: Springer

【 摘 要 】

ObjectiveGenetic polymorphisms in ACE and ACE2 genes are involved in the RAS regulation of blood pressure and their activity may confer susceptibility to hypertension. In addition, they may play a role in SARS-CoV-2 pathogenesis and the severity of COVID-19. This study aims to determine the effect of genetic variations in the ACE (rs4331) and ACE2 (rs2074192) genes with hypertension comorbidity on the severity of COVID-19 in the Indonesian population.Result186 patients were enrolled and assigned into the COVID-19 group (n = 95) and non-COVID-19 group (n = 91) in this cross-sectional study. GG genotype frequency was dominant in ACE gene, but there were no significant differences between the groups (p = 0.163). The two groups had a significant difference (p = 0.000) for the CC genotype frequency (0,37 vs. 0.01) in the ACE2 gene. The proportion of women with COVID-19 is higher (51%), but men with hypertension had more severe symptoms (44%). Men with hypertension comorbidity, GG (ACE), and TT (ACE2) genotypes tended to have moderate-to-severe symptoms (25%). Similarly, women with hypertension as well as GG and CT genotypes tended to have moderate-to-severe symptoms (21%). We conclude that hypertension and mutations in the ACE (rs4331) and ACE2 (rs2074192) genes affect the severity of COVID-19.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

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