A tool for nuclear imaging of the SARS-CoV-2 entry receptor: molecular model and preclinical development of ACE2-selective radiopeptides

EJNMMI Research

Original Research

Christian Vaccarin¹  Ana Katrina Mapanao¹  Pascal V. Grundler¹  Darja Beyer¹  Susan Cohrs¹  Fan Sozzi-Guo¹  Roger Schibli²  Cristina Müller²  Nicholas P. van der Meulen³  Xavier Deupi⁴  Matthias Tanriver⁵  Jinling Wang⁵  Jeffrey W. Bode⁵ 

[1]Center for Radiopharmaceutical Sciences, ETH-PSI, Paul Scherrer Institute, 5232, Villigen-PSI, Switzerland

[2]Center for Radiopharmaceutical Sciences, ETH-PSI, Paul Scherrer Institute, 5232, Villigen-PSI, Switzerland

[3]Institute of Pharmaceutical Sciences, Department of Chemistry and Applied Biosciences, ETH Zurich, 8093, Zurich, Switzerland

[4]Center for Radiopharmaceutical Sciences, ETH-PSI, Paul Scherrer Institute, 5232, Villigen-PSI, Switzerland

[5]Laboratory of Radiochemistry, Paul Scherrer Institute, 5232, Villigen-PSI, Switzerland

[6]Condensed Matter Theory Group, Division of Scientific Computing, Theory, and Data, Paul Scherrer Institute, 5232, Villigen-PSI, Switzerland

[7]Laboratory of Biomolecular Research, Paul Scherrer Institute, 5232, Villigen-PSI, Switzerland

[8]Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland

[9]Institute of Organic Chemistry, Department of Chemistry and Applied Biosciences, ETH Zurich, 8093, Zurich, Switzerland

关键词: DX600;    Radiopeptide;    Gallium;    PET;    ACE2;    ACE;    SARS-CoV-2;   

DOI  :  10.1186/s13550-023-00979-2

 received in 2022-12-12, accepted in 2023-03-29,  发布年份 2023

来源: Springer

【 授权许可】

CC BY   
© The Author(s) 2023

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