期刊论文详细信息
Porcine Health Management
High levels of maternally derived antibodies do not significantly interfere with the development of humoral and cell-mediated responses to Porcine circovirus 2 after intradermal vaccination
Research
Gerard E. Martin-Valls1  Martí Cortey1  Enric Mateu1  Marta Jiménez2  Hanny Swam3 
[1] Departament de Sanitat i Anatomia Animals, Universitat Autònoma de Barcelona, Travessera dels Turons s/n, 08193, Cerdanyola del Vallès, Spain;MSD Animal Health, 37008, Carbajosa de la Sagrada, Spain;MSD CDS, 5831 AN, Boxmeer, The Netherlands;
关键词: Porcine circovirus 2;    Maternally derived antibodies;    Interference;    Immune response;   
DOI  :  10.1186/s40813-023-00335-9
 received in 2023-05-01, accepted in 2023-09-01,  发布年份 2023
来源: Springer
PDF
【 摘 要 】

BackgroundVaccination of pigs against PCV2 is usually performed around weaning when animals still have maternally derived antibodies (MDA). The present study aimed to assess the possible interference of MDA in the development of the PCV2-specific immune response after vaccination of commercial weaners. For this purpose, a PRRS-negative 600-sow farrow-to-finish farm was selected. Half of the sows were vaccinated and revaccinated with Porcilis® PCV ID against PCV2 7 and 3 weeks before farrowing. After farrowing, piglets were tested by AlphaLisa to select 72 animals with high and low levels of MDA. Groups were further subdivided and vaccinated intradermally with Porcilis® PCV ID at 21 or 28 days of age. Unvaccinated controls were also included. Animals were followed afterward for 42 days to examine the development of PCV2-specific antibodies and interferon-γ secreting cells (IFN-γ SC).ResultsThe average titres of antibodies of the groups vaccinated in the presence of low or high MDA levels were similar at 28 and 42 days post-vaccination while in the controls the titres declined throughout the observation period. Results of vaccinating at 21 or 28 days of age were equivalent with regard to antibody development. Regarding the IFN-γ SC, vaccinated animals produced significant frequencies of IFN-γ SC by day 28. Again, no differences were observed between the groups with high or low antibody levels.ConclusionHigh levels of MDA did not interfere with the development of humoral and cell-mediated responses to Porcine circovirus 2 after intradermal vaccination at 21 or 28 days of age.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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【 参考文献 】
  • [1]
  • [2]
  • [3]
  • [4]
  • [5]
  • [6]
  • [7]
  • [8]
  • [9]
  • [10]
  • [11]
  • [12]
  • [13]
  • [14]
  • [15]
  • [16]
  • [17]
  • [18]
  • [19]
  • [20]
  • [21]
  • [22]
  • [23]
  • [24]
  • [25]
  • [26]
  • [27]
  • [28]
  • [29]
  • [30]
  • [31]
  • [32]
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