Association of cardio-renal biomarkers and mortality in the U.S.: a prospective cohort study

Cardiovascular Diabetology

Research

Mingsi Wang¹  Yilan Li²  Fan Yang²  Jianjun Wu²  Yuzhu Chen³ 

[1] College of Health Management of Harbin Medical University, 150076, Harbin, China;Department of Cardiology, the Second Affiliated Hospital of Harbin Medical University, 150086, Harbin, China;Key Laboratory of Myocardial Ischemia, Ministry of Education, 150086, Harbin, China;The Second Affiliated Hospital of Harbin Medical University, 150086, Harbin, China;

关键词: Diabetes;    NHANES;    Predict risk model;    Cardiovascular mortality;    Death burden;   

DOI  :  10.1186/s12933-023-01986-2

 received in 2023-07-26, accepted in 2023-09-07,  发布年份 2023

来源: Springer

【 摘 要 】

ObjectiveDiabetes poses a significant threat to human health. There is a lack of large-scale cohort studies to explore the association between mortality risk and indicators beyond blood glucose monitoring in diabetic populations.MethodsMultivariable Cox proportional hazards regression models were performed to investigate the association of 13 blood biomarkers with mortality risk in the National Health and Nutrition Examination Survey (NHANES) and biomarker levels were log-transformed and correlated with mortality.ResultsDuring a median follow-up of 7.42 years, 1783 diabetic patients were enrolled. Compared to traditional risk factors, the addition of hs-cTnT, hs-cTnI, NT-proBNP, creatinine, cystatin C, and β-2 microglobulin biomarkers increased the predictive ability for all-cause mortality by 56.4%, 29.5%, 38.1%, 18.8%, 35.7%, and 41.3%, respectively. However, the inclusion of blood glucose monitoring had no impact on the prediction of all-cause mortality. Compared with the 1st quartiles of creatinine and Cystatin C, the risk of diabetes mortality were higher in the highest quartiles (HR: 5.16, 95% CI: 1.87–14.22; HR: 10.06, 95% CI: 4.20-24.13).ConclusionsIn the diabetic population, elevated plasma levels of hs-cTnT, hs-cTnI, NT-proBNP, creatinine, cystatin C, and β-2 microglobulin serve as robust and straightforward predictors of long-term mortality compared to blood glucose levels and HbA1c values. Creatinine and cystatin C stand out as more precise markers for predicting diabetes mortality prior to blood glucose monitoring.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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