The effect of intradialytic exercise on calcium, phosphorus and parathyroid hormone: a randomized controlled trial

BMC Nephrology

Research

Farzad Nazemi¹  Mohammad Ali Tabibi¹  Mahsa Soleymany¹  Saghar Ahmadi²  Kenneth R. Wilund³  Saghar Nikbakht⁴  Nasrin Salimian⁵  Zahra Roshanaeian⁶ 

[1] Department of Exercise Physiology, Pardis Specialized Wellness Institute, Isfahan, Iran;Department of Health and Palliative Care, Pardis Specialized Wellness Institute, Isfahan, Iran;Department of Kinesiology and Community Health, Division of Nutritional Sciences, University of Illinois, Urbana-Champaign, USA;Department of Kinesiology, Pardis Specialized Wellness Institute, Isfahan, Iran;Department of Research and Development, Pardis Specialized Wellness Institute, Isfahan, Iran;Department of Sport Nutrition, Pardis Specialized Wellness Institute, Isfahan, Iran;

关键词: Mortality;    Exercise during dialysis;    Bone mineral disorders;    Cardiovascular disease;    Hematological parameters;   

DOI  :  10.1186/s12882-023-03327-7

 received in 2023-06-02, accepted in 2023-09-07,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundPatients with kidney failure experience derangements of circulating markers of mineral metabolism and dysregulation of skeletal and cardiovascular physiology which results in high mortality rate in these patients. This study aimed to evaluate the effect of intradialytic exercise on regulation of these abnormalities in patients receiving chronic hemodialysis (HD).MethodsIn this randomized controlled trial conducted in an HD center in Iran, adult patients receiving chronic HD were randomized to intradialytic exercise (60 min) in the second hour of thrice weekly dialysis for 6 months (intervention) or no intradialytic exercise (control). The primary outcomes were serum calcium, serum phosphorous and parathyroid hormone levels. Secondary outcomes were serum alkaline phosphatase and calcium-phosphorous product.ResultsThe study included 44 participants randomized to intervention (n = 22) or control (n = 22). During the 6-month intervention period, significant between-group changes were observed in all primary and secondary outcomes between the intervention and control groups. Statistical analyses reveal a significant increase in serum calcium (P < 0.05) as well as a significant decrease in serum phosphorous, parathyroid hormone, alkaline phosphatase and calcium-phosphorous product (P < 0.05).ConclusionIntradialytic exercise performed for at least 60 min during thrice weekly dialysis sessions improves bone mineral metabolism in adult patients receiving HD. Further studies should focus on observing and comparing the effect of different types of exercise on bone mineral disorders and all-cause mortality in HD patients.Trial registrationClinicalTrials.gov Identifier: NCT04916743, Registered on 08/06/2021. Registered trial name: The Effect of Intradialytic Exercise on Calcium, Phosphorous and Parathyroid Hormone: A Randomized Controlled Trial.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

【 图 表 】

Fig. 1