Tumor lysis syndrome in premature infant prompting early resection of a large sacrococcygeal teratoma: a case report

BMC Pediatrics

Case Report

Jennifer Mayer¹  Loraine Torres²  Aditi Dey³  Danilo Escoto³  Rita Wyrebek³  Fauzia Shakeel³ 

[1] Cancer and Blood Disorders Institute, Johns Hopkins All Children’s Hospital, Florida, USA;Department of Obstetrics and Gynecology, Bayfront Medical Center, Orlando Health, Florida, USA;Maternal Fetal Neonatal Institute, Johns Hopkins All Children’s Hospital, Florida, USA;

关键词: Glucocorticoids;    Premature infant;    Premature neonates;    Rasburicase;    Hyperkalemia;    Tumor lysis syndrome;    Sacrococcygeal teratoma;    Neonate;   

DOI  :  10.1186/s12887-023-04193-w

 received in 2022-05-18, accepted in 2023-07-17,  发布年份 2023

来源: Springer

【 摘 要 】

BackgroundSacrococcygeal teratomas (SCTs) are the most common congenital neoplasm and often require resection soon after birth. There are rare reports of cardiac arrest during surgery due to manipulation of the tumor triggering secondary necrosis and hyperkalemia.Case presentationThis case describes a very preterm infant with a SCT who develops spontaneous preoperative tumor lysis syndrome (TLS). The medical team utilized rasburicase and the patient underwent total gross resection at 40 h of life.ConclusionsWe emphasize the importance of the early recognition and management of tumor lysis syndrome in SCT with rasburicase, aggressive management of hyperkalemia and consideration of early resection of SCTs even in the case of a very premature infant.

【 授权许可】

CC BY   
© BioMed Central Ltd., part of Springer Nature 2023

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