The role of n terminal - probrain natriuretic peptide in the diagnosis of hemodynamic persistent asrteriosus ductus in premature neonates patient

1st Physics and Technologies in Medicine and Dentistry Symposium

物理学;医药卫生

Dasraf, D.^1 ; Djer, M.M.^1 ; Advani, N.^1

Department of Children Health, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia^1

关键词: Brain natriuretic peptide;    Congenital heart disease;    Cross-sectional study;    Group differences;    Natriuretic peptides;    Patent ductus arteriosus;    Patient population;    Premature neonates;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/884/1/012147/pdf
DOI  :  10.1088/1742-6596/884/1/012147

学科分类：卫生学

来源: IOP

【 摘 要 】

Persistent ductus arteriosus is one of the most frequent congenital heart diseases found in infants, mainly in preterms. Echocardiography is the gold standard for the diagnosis of hemodynamically significant patent ductus arteriosus (hs-PDA) in preterm neonates. A few studies have suggested that the use of a simple blood assay to detect N-terminal pro-brain natriuretic peptide (NT-proBNP) may be useful in determining the diagnosis and management of hs-PDA. No such studies have been conducted in Indonesia, although the assay kit and characteristics of the patient (gestational age and chronological age) influence the accuracy of NT-proBNP levels in determining hs-PDA. The aim of this study was to determine the association between the NT-proBNP level and the prevalence of hs-PDA in an Indonesian patient population. A cross-sectional study was conducted at Dr. Cipto Mangunkusumo Hospital. PDA was determined using echocardiography in 49 preterm neonates (gestational age